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Millipore/05-814 | Anti-HDAC2 Antibody, clone 3F3/05-814/200 µg
  • Millipore/05-814 | Anti-HDAC2 Antibody, clone 3F3/05-814/200 µg

Millipore/05-814 | Anti-HDAC2 Antibody, clone 3F3/05-814/200 µg

價(jià)格: ￥4680.00 市場(chǎng)價(jià): 7800.00
貨號(hào): 05-814
品牌: Millipore
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    • Description
      CatalogueNumber05-814
      Replaces04-229
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-HDAC2Antibody,clone3F3
      AlternateNames
      • YY1-associatedfactor1
      • histonedeacetylase2
      • transcriptionalregulatorhomologRPD3
      BackgroundInformationHistonedeacetylase2(HDAC2),ortranscriptionalregulatorhomologRPD3L1,ishighlyhomologoustotheyeasttranscriptionfactorRPD3(reducedpotassiumdependency3)gene.Asinyeast,humanHDA2islikelytobeinvolvedinregulatingchromatinstructureduringtranscription.IthasbeenimplicatedtoassociatewithYY1,amammalianzinc-fingertranscriptionfactor,whichnegativelyregulatestranscriptionbytetheringRPD3toDNAasacofactor.Thisprocessishighlyconservedfromyeasttohuman.
      ProductInformation
      FormatPurified
      Control
      • IncludedPositiveAntigenControl:Catalog#12-309,HeLanuclearextract.AddanequalvolumeofLaemmlireducingsamplebufferto10μLofextractandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
      PresentationPurifiedmousemonoclonalIgGinbuffercontaining70%storagebuffer(0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazide)and30%glycerol.Storeat-20°C.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      Applications
      ApplicationAnti-HDAC2Antibody,clone3F3isaMouseMonoclonalAntibodyfordetectionofHDAC2alsoknownasYY1-associatedfactor1,histonedeacetylase2&hasbeenvalidatedinICC,IP&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunocytochemistry:
      ThisantibodyhasbeenreportedbyanindependentlaboratorytoshowpositiveimmunostainingforHDAC2inNIH/3T3andU2OScellsfixedwithparaformaldehyde.

      ImmunoprecipitationandHDACAssay:
      3μLofapreviouslotwasusedtoimmunoprecipitateHDACactivityfromHeLanuclearextract,whichwasthenmeasuredusingtheHDACAssayKit(FluorometricDetection)(Catalog#17-356).Anindependentlaboratoryhasalsodemonstratedpositiveimmunoprecipitation/HDACassayresultsusingNIH/3T3cells.
      BIOLOGicalInformation
      ImmunogenKLH-conjugated,syntheticpeptide(CEKTDTKGTKSEQLSNP)correspondingtoaminoacids473-488ofhumanHDAC2(Accession#NP_001518)containingaN-terminalcysteine
      Clone3F3
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityRecognizesHDAC2,MW~60kDa.
      IsotypeIgG1
      SpeciesReactivity
      • Human
      • Bovine
      • Mouse
      • Rat
      • Hamster
      SpeciesReactivityNoteHuman,mouse,bovineandhamster.Predictedtocross-reactwithratbasedonsequencehomology.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneproductbelongstothehistonedeacetylasefamily.HistonedeacetylasesactviatheformationoflargemultiproteincomplexesandareresponsIBLeforthedeacetylationoflysineresiduesontheN-terminalregionofthecorehistones(H2A,H2B,H3andH4).Thisproteinalsoformstranscriptionalrepressorcomplexesbyassociatingwithmanydifferentproteins,includingYY1,amammalianzinc-fingertranscriptionfactor.Thusitplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.
      GeneSymbol
      • HDAC2
      • HD2
      • YAF1
      • RPD3
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q92769#FormstranscriptionalrepressorcomplexesbyassociatingwithMAD,SIN3,YY1andN-COR.InteractsinthelateS-phaseofDNA-replicationwithDNMT1intheothertranscriptionalrepressorcomplexcomposedofDNMT1,DMAP1,PCNA,CAF1.
      SIZE:488aminoacids;55364Da
      SUBUNIT:Interactswiththenon-histoneregionofH2AFY(Bysimilarity).Partofthecorehistonedeacetylase(HDAC)complexcomposedofHDAC1,HDAC2,RBBP4andRBBP7.ThecorecomplexassociateswithMTA2,MBD3,MTA1L1,CHD3andCHD4toformthenucleosomeremodelingandhistonedeacetylation(NuRD)complex,orwithSIN3,SAP18andSAP30toformtheSIN3HDACcomplex.ComponentofaBHChistonedeacetylasecomplexthatcontainsHDAC1,HDAC2,HMG20B/BRAF35,AOF2/LSD1,RCOR1/CoRESTandPHF21A/BHC80.TheBHCcomplexmayalsocontainZMYM2,ZNF217,ZMYM3,GSE1andGTF2I.PartofacomplexcontainingthecorehistonesH2A,H2B,H3andH4,DEKandunphosphorylatedDAXX.PartofacomplexcontainingATRandCHD4.FormsaheterologouscomplexatleastwithYY1.InteractswithATR,DNMT1,MINT,HDAC7,HDAC10,HCFC1,NRIP1,MJD2A/JHDM3A,SAP30,SETDB1andSUV39H1.Interactswiththenon-histoneregionofH2AFY.InteractswithPELP1.ComponentofamSin3AcorepressorcomplexthatcontainsSIN3A,SAP130,SUDS3/SAP45,ARID4B/SAP180,HDAC1andHDAC2.InteractswithCBFA2T3.InteractswithSAP30L.
      SUBCELLULARLOCATION:Nucleus.TISSUESPECIFICITY:Widelyexpressed;lowerlevelsinbrainandlung.
      SIMILARITY:SwissProt:Q92769##Belongstothehistonedeacetylasefamily.Type1subfamily.
      MolecularWeight~60kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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