Immunogen | Fusionproteincorrespondingtoaminoacids152-340ofthebeta1subunit |
Host | Rabbit |
Specificity | Na+/K+ATPaseβ-1 |
Isotype | IgG |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | TheproteinencodedbythisgenebelongstothefamilyofNa+/K+andH+/K+ATPasesbetachainproteins,andtothesubfamilyofNa+/K+-ATPases.Na+/K+-ATPaseisanintegralmembraneproteinresponsIBLeforestablishingandmaintainingtheelectRochemicalgrADIentsofNaandKionsacrosstheplasmamembrane.Thesegradientsareessentialforosmoregulation,forsodium-coupledtransportofavarietyoforganicandinorganicmolecules,andforelectricalexcitABIlityofnerveandmuscle.Thisenzymeiscomposedoftwosubunits,alargecatalyticsubunit(alpha)andasmallerglycoproteinsubunit(beta).Thebetasubunitregulates,throughassemblyofalpha/betaheterodimers,thenumberofsodiumpumpstransportedtotheplasmamembrane.TheglycoproteinsubunitofNa+/K+-ATPaseisencodedbymultiplegenes.Thisgeneencodesabeta1subunit.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified. |
GeneSymbol | - ATP1B1
- MGC1798
- adenosinetriphosphatase
- ATP1B
|
PurificationMethod | Antiserum |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P05026#Thisisthenon-catalyticcomponentoftheactiveenzyme,whichcatalyzesthehydrolysisofATPcoupledwiththeexchangeofNa(+)andK(+)ionsacrosstheplasmamembrane.Thebetasubunitregulates,throughassemblyofalpha/betaheterodimers,thenumberofsodiumpumpstransportedtotheplasmamembrane. SIZE:303aminoacids;35061Da SUBUNIT:Composedofthreesubunits:alpha(catalytic),betaandgamma.InteractswithNKAIN1,NKAIN2andNKAIN4(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeIImembraneprotein. TISSUESPECIFICITY:Foundinmosttissues. SIMILARITY:SwissProt:P05026##BelongstotheX(+)/potassiumATPasessubunitbetafamily. |
MolecularWeight | 48/52kDa |