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Millipore/06-863 | Anti-CREB Antibody/06-863/200 µg
  • Millipore/06-863 | Anti-CREB Antibody/06-863/200 µg

Millipore/06-863 | Anti-CREB Antibody/06-863/200 µg

價(jià)格: ￥3816.00 市場(chǎng)價(jià): 6360.00
貨號(hào): 06-863
品牌: Millipore
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    • Description
      CatalogueNumber06-863
      Replaces04-218
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-CREBAntibody
      AlternateNames
      • CyclicAMP-responsiveelement-bindingprotein1
      • cAMP-responsiveelement-bindingprotein1
      • CREB-1
      BackgroundInformationCyclicAMP-responsiveelement-bindingprotein1(UniProtP16220;alsoknownascAMP-responsiveelement-bindingprotein1,CREB-1)isencodedbytheCREB1gene(GeneID1385)inhuman.CREBisatranscriptionfactorthatbindsthecAMPresponseelements(CRE)andregulatesthetranscriptionofthedownstreamgenes.CREBactivityisregulationviaphosphorylationbyvariouskinases,includingPKA,andCa2+/calmodulin-dependentproteinkinases.GenesknowntoberegulatedbyCREBincludec-fos,BDNF,tyrosinehydroxylase,neuropeptides(suchassomatostatin,enkephalin,VGF,andcorticotropin-releasinghormone),aswellasthecircADIanclockgenesPER1andPER2.CREBiscriticalformemoryformationacrossawiderangeofspecies.
      ProductInformation
      FormatProteinAPurified
      Control
      • HeLanuclearextract
        IncludedPositiveAntigenControl:Catalog#12-309,HeLanuclearextract.AddanequalvolumeofLaemmlireducingsamplebufferto5-10μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
      PresentationPurifiedrabbitpolyclonalantibodyinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazidewith30%glycerol.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationAnti-CREBAntibody,Cat.No.06-863,isahighlyspecificrabbitPolyclonalantibody,thattargetsCREBandhasbeentestedinChromatinImmunoprecipitation(ChIP),ChIP-seq,ElectrophoreticMobilityShiftAssay(EMSA),Immunoprecipitation,andWesternBlotting.
      KeyApplications
      • WesternBlotting
      • Immunoprecipitation
      • ChromatinImmunoprecipitation(ChIP)
      • ChIP-seq
      • ElectrophoreticMobilityShiftAssay
      ApplicationNotesImmunoprecipitationAnalysis:10μgfromarepresentativelotimmunoprecipitatedCREBin500μgofHeLanuclearextract.
      ChromatinImmunoprecipitation(ChIP)Analysis:ArepresentativelotdetectedanenhancedCREBoccupancyattheLYPD3promoterinLKB1-deficientTE-4humanesophagealcancercells(Gu,Y.,etal.(2012).Oncogene.31(4):469–479).
      ChromatinImmunoprecipitation(ChIP)Analysis:ArepresentativelotdetectedCREBassociationattheRNASET2sitestargetedbyT-cellLeukemiaVirustype1(HTLV-1)encodedTaxproteinusingHTLV-1-infectedhumanT-celllines,MT-2,C8166/45andSLB-1(Polakowski,N.,etal.(2011).Viruses.3(8):1485-500).
      ChromatinImmunoprecipitation(ChIP)Analysis:ArepresentativelotdetectedCREBoccupancyatthehBDNFpromoterIVusingpostmortemhumanparietalcortextissuechromatinpreparations(Pruunsild,P.,etal.(2011).J.Neurosci.31(9):3295-3308).
      ChromatinImmunoprecipitation(ChIP)Analysis:ArepresentativelotdetectedCREBoccupancyatthemiR-9-2promoterinSK-N-BEhumanneuroblastomacells(Laneve,P.,etal.(2010).Nucl.AcidsRes.38(20):6895-6905).
      ChIP-seqAnalysis:ArepresentativelotidentifiedCREBtargetgenesinmurinespermatogoniaderivedGC1-spgcellsbyChIP-seqanalysis(Martianov,I.,etal.(2010).BMCGenomics.11:530).
      WesternBlottingAnalysis:RepresentativelotsdetectedCREBinlysatesfromculturedembryonicratstriatalneuronsandPC12pheochromocytomacells(Hutchinson,A.N.,etal.(2012).Neuropsychopharmacology.37(2):321-337;Maharjan,S.,etal.(2010).J.NeuRochem.112(1):42-55).
      WesternBlottingAnalysis:RepresentativelotsdetectedCREBinmouseproximalcaputepididymis-1(PC-1)celllysateandhippocampustissuehomogenates(Hamzeh,M.,andRobaire,B.(2011).J.Endocrinol.209(1):55-64;Zhou,Z.,etal.(2009).Neuropharmacology.56(1):81-89).
      WesternBlottingAnalysis:ArepresentativelotdetectedCREBinSK-N-BEhumanneuroblastomacelllysate(Laneve,P.,etal.(2010).Nucl.AcidsRes.38(20):6895-6905).
      ElectrophoreticMobilityShiftAssay(EMSA):ArepresentativelotcausedasupershiftofDNA-CREBcomplexinEMSAusingradiolabeledoligonucleotidecontaininghBDNFpromoterICREB-bindingsequenceandlysatesfromKCl-treatedprimaryratneurons(Pruunsild,P.,etal.(2011).J.Neurosci.31(9):3295-3308).
      BIOLOGicalInformation
      ImmunogenKLH-conjugated,syntheticpeptide(CSGAENQQSGDAAVTEAENQQ)correspondingtoa.a.5-24ofhumanCREB.Theimmunizingsequenceisidenticalinpig,shares19of20residueswithmouseandbovineand18of20residueswithrat.
      EpitopeAminoacids5-24.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesCREB.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteHuman,Mouse,Rat.PredictedtoreactwithCanine,Horse,Porcinebasedon100%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesatranscriptionfactorthatisamemberoftheleucinezipperfamilyofDNAbindingproteins.ThisproteinbindsasahomodimertothecAMP-responsiveelement,anoctamericpalindrome.Theproteinisphosphorylatedbyseveralproteinkinases,andinducestranscriptionofgenesinresponsetohormonalstimulationofthecAMPpathway.Alternatesplicingofthisgeneresultsintwotranscriptvariantsencodingdifferentisoforms.
      GeneSymbol
      • CREB1
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P16220#ThisproteinbindsthecAMPresponseelement(CRE),asequencepresentinmanyviralandcellularpromoters.CREBstimulatestranscriptiononbindingtotheCRE.
      SIZE:341aminoacids;36688Da
      SUBUNIT:BindsDNAasadimer.InteractsPPRC1andwithHTLV-1Tax-1.
      SUBCELLULARLOCATION:Nucleus.
      PTM:Stimulatedbyphosphorylation.PhosphorylationofbothSer-133andSer-142intheSCNregulatestheactivityofCREBandparticipatesincircadianrhythmgeneration.PhosphorylationofSer-133allowsCREBBPandEP300binding(Bysimilarity).PhosphorylateduponDNAdamage,probablybyATMorATR.
      SIMILARITY:SwissProt:P16220##BelongstothebZIPfamily.&Contains1bZIPdomain.&Contains1KID(kinase-inducIBLe)domain.
      MolecularWeight~43kDaobserved.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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