UniProtSummary | FUNCTION:SwissProt:O15379#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.Probablyparticipatesintheregulationoftranscriptionthroughitsbindingtothezinc-fingertranscriptionfactorYY1;increasesYY1repressionactivity.RequiredtorepresstranscriptionofthePOU1F1transcriptionfactor. SIZE:428aminoacids;48848Da SUBUNIT:InteractswithHDAC7andHDAC9.FormsaheterologouscomplexatleastwithYY1.InteractswithDAXX,HDAC10andDACH1.FoundinacomplexwithNCOR1andNCOR2.ComponentoftheN-Correpressorcomplex,atleastcomposedofNCOR1,NCOR2,HDAC3,TBL1X,TBL1R,CORO2AandGPS2.InteractswithBCOR,MJD2A/JHDM3A,NRIP1andSRY.InteractswithBTBD14B.InteractswithGLIS2(Bysimilarity).InteractswithCBFA2T3. SUBCELLULARLOCATION:Nucleus. TISSUESPECIFICITY:Widelyexpressed. PTM:Sumoylatedinvitro. SIMILARITY:SwissProt:O15379##Belongstothehistonedeacetylasefamily.Type1subfamily. |