Immunogen | SyntheticpeptidecorrespondingaminoacidswiththeC-terminusofhumanGLUT-1coupledtoKLH(C-ELFHPLGADSQV). |
Epitope | C-Terminus |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | ThisrabbitpolyclonalantibodydetectsGLUT-1inhumanandmousecells.Ittargetsanepitopewithin12aminoacidsfromtheC-terminalhalf.
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Isotype | IgG |
SpeciesReactivity | |
SpeciesReactivityNote | Human.Mouse.PredictedtoreactwithRatbasedon100%sequencehomology.
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AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesamajorglucosetransporterinthemammalianblood-brainbarrier.Mutationsinthisgenehavebeenfoundinafamilywithparoxysmalexertion-induceddyskinesia.[providedbyRefSeq].
|
GeneSymbol | - GLUT
- GLUT-1
- GLUT1
- MGC141895
- MGC141896
|
PurificationMethod | AffinityPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:Facilitativeglucosetransporter.Thisisoformmayberesponsibleforconstitutiveorbasalglucoseuptake.Hasaverybroadsubstratespecificity;cantransportawiderangeofaldosesincludingbothpentosesandhexoses. SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein(Bysimilarity).Melanosome.Note=Localizesprimarilyatthecellsurface(Bysimilarity).IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV. TISSUESPECIFICITY:Expressedatvariablelevelsinmanyhumantissues. PTM:PhosphorylateduponDNAdamage,probablybyATMorATR. DISEASE:DefectsinSLC2A1arethecauseofautosomaldominantGLUT1deficiencysyndrome[MIM:606777].Thisdiseasecausesadefectinglucosetransportacrosstheblood-brainbarrier.Itischaracterizedbyinfantileseizures,delayeddevelopment,andacquiredmicrocephaly. SIMILARITY:Belongstothemajorfacilitatorsuperfamily.Sugartransporter(TC2.A.1.1)family.Glucosetransportersubfamily[viewclassification].
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MolecularWeight | Thisantibodydetectsamajorband~54kDainWesternblotanalysis. |