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Millipore/07-1643 | Anti-phospho-Akt (Tyr450) Antibody/07-1643/100 µg
  • Millipore/07-1643 | Anti-phospho-Akt (Tyr450) Antibody/07-1643/100 µg

Millipore/07-1643 | Anti-phospho-Akt (Tyr450) Antibody/07-1643/100 µg

價格: ￥3324.00 市場價: 5540.00
貨號: 07-1643
品牌: Millipore
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    • Description
      CatalogueNumber07-1643
      DescriptionAnti-phospho-Akt(Tyr450)Antibody
      AlternateNames
      • AKT1kinase
      • ProteinkinaseB
      • RAC-alphaserine/threonine-proteinkinase
      • racproteinkinasealpha
      • v-aktmurinethymomaviraloncogenehomolog1
      BackgroundInformationAkt(proteinkinaseB),aserine/threoninekinase,hasemergedasacriticalenzymeinsignaltransductionpathwaysinvolvedincellproliferation,apoptosis,angiogenesis,anddiabetes.InmammalsthreeisoformsofAkt(α,β,γorAkt1,2,3)arereportedthatexhibitahighdegreeofhomology,butdifferslightlyinthelocalizationoftheirregulatoryphosphorylationsites.Aktαisthepredominantisoforminmosttissues,whereasthehighestexpressionofAktβisobservedintheinsulin-responsivetissues,andAktγisabundantinbraintissue.EachAktisoformiscomposedofthreefunctionallydistinctregions:anN-terminalpleckstrinhomology(PH)domainthatprovidesalipid-bindingmoduletodirectAkttoPIP2andPIP3,acentralcatalyticdomain,andaC-terminalhydrophobicmotif.
      ProductInformation
      FormatAffinityPurified
      Control
      • LamBDaphosphatasetreatedanduntreatedNIH/3T3withAnisomycin,RAT2withSRC,andMCF7withEGF
      PresentationAffinitypurifiedrabbitseruminbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-phospho-Akt(Tyr450)Antibodyisanantibodyagainstphospho-Akt(Tyr450)foruseinWB,EA.
      KeyApplications
      • WesternBlotting
      • EnzymeAssays
      ApplicationNotesWesternBlot(SNAPID)Analysis:1:1,000dilutionfromapreviouslotdetectedAKTphosphorylatedatTyr450inNIH/3T3celllysate.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtohumanphosphorylatedAKTatandaroundTyr450.
      EpitopePhosphorylatedTyr450
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesphosphorylatedAktatTyr450.
      SpeciesReactivity
      • Mouse
      • Rat
      • Human
      • Bovine
      • Chicken
      • Horse
      SpeciesReactivityNoteReactswithhuman,mouse,andrat.Predictedtoreactwithcow,chicken,andhorsebasedonsequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheserine-threonineproteinkinaseencodedbytheAKT1geneiscatalyticallyinactiveinserum-starvedprimaryandimmortalizedfibroblasts.AKT1andtherelatedAKT2areactivatedbyplatelet-derivedgrowthfactor.Theactivationisrapidandspecific,anditisabrogatedbymutationsinthepleckstrinhomologydomainofAKT1.Itwasshownthattheactivationoccursthroughphosphatidylinositol3-kinase.InthedevelopingnervoussystemAKTisacriticalmediatorofgrowthfactor-inducedneuronalsurvival.Survivalfactorscansuppressapoptosisinatranscription-independentmannerbyactivatingtheserine/threoninekinaseAKT1,whichthenphosphorylatesandinactivatescomponentsoftheapoptoticmachinery.Multiplealternativelysplicedtranscriptvariantshavebeenfoundforthisgene.[providedbyRefSeq]
      GeneSymbol
      • AKT1
      • RAC
      • PRKBA
      • RAC-ALPHA
      • RAC-PK-alpha
      • C-AKT
      • PKB
      • AKT
      Modifications
      • Phosphorylation
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Generalproteinkinasecapableofphosphorylatingseveralknownproteins.PhosphorylatesTBC1D4.Signalsdownstreamofphosphatidylinositol3-kinase(PI(3)K)tomediatetheeffectsofvariousgrowthfactorssuchasplatelet-derivedgrowthfactor(PDGF),epidermalgrowthfactor(EGF),insulinandinsulin-likegrowthfactorI(IGF-I).Playsaroleinglucosetransportbymediatinginsulin-inducedtranslocationoftheGLUT4glucosetransportertothecellsurface.MediatestheantiapoptoticeffectsofIGF-I.Mediatesinsulin-stimulatedproteinsynthesis,partlybyplayingaroleinbothinsulin-inducedphosphorylationof4E-BP1andininsulin-inducedactivationofp70S6kinase.Promotesglycogensynthesisbymediatingtheinsulin-inducedactivationofglycogensynthase.

      SIZE:480aminoacids;55686Da

      SUBUNIT:InteractswithCENTG1isoform2(PIKE-A)inthepresenceofguaninenucleotides.TheC-terminusinteractswithCCDC88A/GRDN.InteractswithAKTIP.

      SUBCELLULARLOCATION:Cytoplasm.Nucleus.Note=Nucleusafteractivationbyintegrin-linkedproteinkinase1(ILK1).

      TISSUESPECIFICITY:Inallhumancelltypessofaranalyzed.

      DOMAIN:BindingofthePHdomaintothephosphatidylinositol3-kinasealpha(PI(3)K)resultsinitstargetingtotheplasmamembrane.

      PTM:PhosphorylationonThr-308,Ser-473andTyr-474isrequiredforfullactivity.Ser-473phosphorylationbytheRictor-mTorcomplexfavorsThr-308phosphorylationbyPDPK1.Ser-473phosphorylationisenhancedbyinteractionwithCENTG1isoform2(PIKE-A).

      SIMILARITY:Belongstotheproteinkinasesuperfamily.AGCSer/Thrproteinkinasefamily.RACsubfamily.&Contains1AGC-kinaseC-terminaldomain.&Contains1PHdomain.&Contains1proteinkinasedomain.
      MolecularWeightApprox.56kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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