Immunogen | peptidecorrespondingtoaminoacids1035-1053(C-GKRNRHSSQTSEESAIETG)ofhumanPDGFReceptorα |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | RecognizesPDGFReceptoralpha. |
Isotype | IgG |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesacellsurfacetyrosinekinasereceptorformembersoftheplatelet-derivedgrowthfactorfamily.Thesegrowthfactorsaremitogensforcellsofmesenchymalorigin.Theidentityofthegrowthfactorboundtoareceptormonomerdetermineswhetherthefunctionalreceptorisahomodimeroraheterodimer,composedofbothplatelet-derivedgrowthfactorreceptoralphaandbetapolypeptides.Studiesinknockoutmice,wherehomozygosityislethal,indicatethatthealphaformoftheplatelet-derivedgrowthfactorreceptorisparticularlyimportantforkidneydevelopmentsincemiceheterozygousforthereceptorexhibitdefectivekidneyphenotypes. |
GeneSymbol | - PDGFRA
- CD140a
- PDGF-R-alpha
- MGC74795
- PDGFR2
- Rhe-PDGFRA
- CD140A
|
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P16234#ReceptorthatbindsbothPDGFAandPDGFBandhasatyrosine-proteinkinaseactivity. SIZE:1089aminoacids;122670Da SUBUNIT:Homodimer,andheterodimerwithPDGFRB.InteractswithSHB(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. DISEASE:SwissProt:P16234#AfusionofPDGFRAandFIP1L1(FIP1L1-PDGFRA),duetoaninterstitialchromosomaldeletion,isthecauseofsomecasesofhypereosinophilicsyndrome(HES)[MIM:607685].HESisararehematologicdisordercharacterizedbysustainedoverproductionofeosinophilsinthebonemarrow,eosinophilia,tissueinfiltrationandorgandamage. SIMILARITY:SwissProt:P16234##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.CSF-1/PDGFreceptorsubfamily.&Contains5Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain. |
MolecularWeight | 150/170kDa(doublet) |