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Millipore/07-382 | Anti-acetyl-Histone H2B (Lys5) Antibody/07-382/100 µg
  • Millipore/07-382 | Anti-acetyl-Histone H2B (Lys5) Antibody/07-382/100 µg

Millipore/07-382 | Anti-acetyl-Histone H2B (Lys5) Antibody/07-382/100 µg

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貨號: 07-382
品牌: Millipore
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    • Description
      CatalogueNumber07-382
      TradeName
      • Upstate
      DescriptionAnti-acetyl-HistoneH2B(Lys5)Antibody
      AlternateNames
      • HistoneH2Btype3-B
      • H2Btype12
      BackgroundInformationHistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.Thehistoneshaveanaminoterminaltail,aglobulardomain,andacarboxy-terminaltail.Thefourcorehistones,H2A,H2B,H3andH4assembleintotheoctamer(2moleculesofeach).Subsequently,146basepairsofDNAarewrappedinasequence-independentmanneraroundtheoctamer,formingthebasicsubunitofchromatin,thenucleosome.HistoneH4isoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH4isinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.
      ProductInformation
      FormatAffinityPurified
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-acetyl-HistoneH2B(Lys5)AntibodyisaRabbitPolyclonalAntibodyfordetectionofacetyl-HistoneH2B(Lys5)alsoknownasH2BK5Ac,HistoneH2B(acetylK5)&hasbeenvalidatedinWB.
      KeyApplications
      • WesternBlotting
      • DotBlot
      • Immunoprecipitation
      ApplicationNotesDotBlot(Specificity)Analysis:0.5μg/mLfromarepresentativelotdetectedacetylHistoneH2B(Lys5)inanAbSurance?HistoneH3AntibodySpecificityArray(Cat.No.16-667)andanAbSurance?HistoneH2A,H2B,H4AntibodySpecificityArray(Cat.No.16-665),bothofwhichcontainunmodifiedandmodifiedHistonepeptides.

      ImmunoprecipitationAnalysis:10μg/mLfromarepresentativelotimmunoprecipitatedacetylHistoneH2B(Lys5)from500μgofsodiumbutyratetreatedHeLaacidextract.Immunoprecipitatedsamplewasthenprobedwith2μg/mLofthesameantibodyinWesternBlotting.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtotheN-terminusofhumanHistoneH2BacetylatedatLys5.
      EpitopeN-terminus
      Concentration1.0mg/mL
      HostRabbit
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteHuman.PredictedtoreactwithVertebratesbasedon100%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH2Bfamily.Transcriptsfromthisgenecontainapalindromicterminationelement.
      GeneSymbol
      • HIST3H2BB
      Modifications
      • Acetylation
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q8N257#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      SIZE:126aminoacids;13908Da
      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      SUBCELLULARLOCATION:Nucleus.
      PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.&PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination.
      SIMILARITY:SwissProt:Q8N257##BelongstothehistoneH2Bfamily.
      MolecularWeight~16kDaobserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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