UniProtSummary | FUNCTION:SwissProt:Q9BY41#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes. SIZE:377aminoacids;41758Da SUBUNIT:InteractswithPEPB2-MYH11,afusionproteinconsistingofthe165N-terminalresiduesofCBF-beta(PEPB2)withthetailregionofMYH11producedbytheinversionInv(16)(p13q22),atranslocationassociatedwithacutemyeloidleukemiaofM4EOsubtype.ThePEPB2-MYH1fusionproteinalsointeractswithRUNX1,awellknowntranscriptionalregulator,suggestingthattheinteractionwithHDAC8mayparticipateintheconversionofRUNX1intoaconstitutivetranscriptionalrepressor.InteractswithCBFA2T3. SUBCELLULARLOCATION:Nucleus.Note=Excludedfromthenucleoli.TISSUESPECIFICITY:Weaklyexpressedinmosttissues.Expressedathigherlevelinheart,brain,kidneyandpancreas. SIMILARITY:SwissProt:Q9BY41##Belongstothehistonedeacetylasefamily.Type1subfamily. MISCELLANEOUS:ItsactivityisinhibitedbytrichostatinA(TSA)andbutyrate,twowellknownhistonedeacetylaseinhibitors. |