BackgroundInformation | HDAC11isresponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).HistonedeacetylationisaMarkerforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.ThepredominantlynuclearHDAC11,whichinteractswithHDAC6,isweaklyexpressedinmosttissues,andstronglyexpressedinbrain,heart,skeletalmuscle,kidneyandtestis.Itsactivityisinhibitedbytrapoxin,aknownhistonedeacetylaseinhibitor. |