GadoSpinFisanamphiphilicgadolinium-basedcontrastagentwithhighprotein-bindingaffinityspecificallyformulatedforpreclinicalmagneticresonanceimaging(MRI).
ItisacontrastagentofhighrelaxivityincreasingthesignalintensityinT1-weightedMRIduetoashorteningofthespin-latticerelaxationtime(T1).
Uponintravenousinjection,GadoSpinFrapidlybindstoplasmaproteins.Thisproteinbindingextendstheresidencetimeofthedruginthevascularspaceand,consequently,prolongstheimagingtimewindow.Accumulationinatheroscleroticplaquescanbeobservedallowingfordirectvisualizationofplaqueburden.
GadoSpinFisexcretedinfecesandurine.
GadoSpinFisindicatedforuseinMRIofsmallanimals,forexamplemice,tofacilitatethevisualizationofthevasculature.
Examplesincludecontrast-enhancedmagneticresonanceangiography(MRA)anddetectionofatheroscleroticplaques.