Magneticresonanceimaging(MRI)isthemostfrequentlyusedtechniqueforserial
invivocelltrackingapplicationsduetohighresolutionofsofttissues,whichmakesitespeciallyusefulforimagingofthebrain,muscles,ortheheart.1Inordertoimprovedetect
ABIlityoftransplantedcellsandproduceastrongcontrastagainstsurroundingtissue,intracellularlabelingofcellswithironoxideparticlesbeforetransplantationhasbeendescribed.2OurnewlydevelopedFeraTrackContrastParticlesaresuperparamagneticironoxide(SPIO)particlesspecificallyformulatedfor
invitrolabelingofvariouscelltypespriortotransplantationandpre-clinicalMRI.Oncewithincells,SPIOscaninducedecreasedsignalintensityonT1,T2,andT2*-weightedimages.3