TheAnti-PSA-NCAMantibodyrecognizesanepitopeonpolysialicacid(PSA)which,invertebrates,isfoundlinkedtotheextracellulardomainoftheneuralcelladhesionmolecule(NCAM,CD56).1PSA-NCAM,thehighlypolysialatedformofNCAM,ispredominantlyexpressed
inembryonicandneonatalneuraltissue.2Invitrodifferentiationofhumanandmousepluripotentstemcellsunderdefinedconditionsrevealedthatneuronalprogenitors,e.g.long-termself-renewingneuroepithelial-likestemcells,expressthesurface
MarkerPSA-NCAM.3Magneticallyenriched,invitrogeneratedPSA-NCAMpositiveneuralprogenitorscanbefurtherdifferentiatedintodefinedneuronalsubtypes.