CloneREA373recognizesthehumanandmouseBcl-6antigen,amemberoftheBTB-zincfingerfamilyofproteins.Bcl-6isatranscriptionalrepressor,expressedingerminalcenterTandBcellsandinprimaryimmaturedendriticcells.Itplayscriticalfunctionsinvariouscelltypeswithintheadaptiveandinnatecompartmentsoftheimmunesystem.Bcl-6ishighlyup-regulatedinBcellsafterTcell–dependentantigenicchallenge,andisrequiredforformationofgerminalcenterswithinwhichBcellsundergoimmunoglobulinaffinitymaturation.Italsoplaysanimportantroleinmacrophages,whereitmediatesadampeningeffectoninflammatorysignalingthroughrepressionofchemokineexpressionandNF-κBtargetgenes.
Additionalinformation:CloneREA373displaysneglig
IBLebindingtoFcreceptors.