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Millipore/16-305 | Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone 11E6, Alexa Fluor? 488/16-305/50 µg
  • Millipore/16-305 | Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone 11E6, Alexa Fluor? 488/16-305/50 µg

Millipore/16-305 | Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone 11E6, Alexa Fluor? 488/16-305/50 µg

價(jià)格: ￥3444.00 市場(chǎng)價(jià): 5740.00
貨號(hào): 16-305
品牌: Millipore
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    • Description
      CatalogueNumber16-305
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-phospho-Akt1/PKBα(Ser473)Antibody,clone11E6,AlexaFluor?488
      AlternateNames
      • PKB
      • PKD-alpha
      • AKT1
      • ProteinKinaseB
      ProductInformation
      FormatAlexaFluor?488
      StorageandShippingInformation
      StorageConditions1yearat4°Cfromdateofshipment
      Applications
      ApplicationDetectphospho-Akt1/PKBα(Ser473)usingthisAnti-Akt1Antibody,clone11E6,AlexaFluor488validatedforuseinFC,IC,IF&WB.
      KeyApplications
      • FlowCytometry
      • Immunocytochemistry
      • Immunofluorescence
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenKLHconjugatedsyntheticpeptidecontainingapSerthatcorrespondstoaminoacidresiduesaroundphosphoserine473.
      Clone11E6
      HostMouse
      SpecificityRecognizesphosphorylatedAkt1/PKBαatSer473.Thislotofantibodydoesnotcross-reactwithAkt1/PKBαdephosphorylatedatSer473.
      IsotypeIgG1
      SpeciesReactivity
      • Canine
      • Human
      • Mouse
      • Rat
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheserine-threonineproteinkinaseencodedbytheAKT1geneiscatalyticallyinactiveinserum-starvedprimaryandimmortalizedfibroblasts.AKT1andtherelatedAKT2areactivatedbyplatelet-derivedgrowthfactor.Theactivationisrapidandspecific,anditisabrogatedbymutationsinthepleckstrinhomologydomainofAKT1.Itwasshownthattheactivationoccursthroughphosphatidylinositol3-kinase.InthedevelopingnervoussystemAKTisacriticalmediatorofgrowthfactor-inducedneuronalsurvival.Survivalfactorscansuppressapoptosisinatranscription-independentmannerbyactivatingtheserine/threoninekinaseAKT1,whichthenphosphorylatesandinactivatescomponentsoftheapoptoticmachinery.Multiplealternativelysplicedtranscriptvariantshavebeenfoundforthisgene.
      GeneSymbol
      • AKT1
      • RAC
      • PRKBA
      • MGC99656
      • RAC-ALPHA
      • RAC-PK-alpha
      • C-AKT
      • PKB
      • AKT
      Modifications
      • Phosphorylation
      PurificationMethodPurifiedfromserum-freecellculturesupernatantbysubsequentthiophilicadsorptionandsizeexclusionchromatography
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P31749#Generalproteinkinasecapableofphosphorylatingseveralknownproteins.PhosphorylatesTBC1D4.Signalsdownstreamofphosphatidylinositol3-kinase(PI(3)K)tomediatetheeffectsofvariousgrowthfactorssuchasplatelet-derivedgrowthfactor(PDGF),epidermalgrowthfactor(EGF),insulinandinsulin-likegrowthfactorI(IGF-I).Playsaroleinglucosetransportbymediatinginsulin-inducedtranslocationoftheGLUT4glucosetransportertothecellsurface.MediatestheantiapoptoticeffectsofIGF-I.Mediatesinsulin-stimulatedproteinsynthesis,partlybyplayingaroleinbothinsulin-inducedphosphorylationof4E-BP1andininsulin-inducedactivationofp70S6kinase.Promotesglycogensynthesisbymediatingtheinsulin-inducedactivationofglycogensynthase.
      SIZE:480aminoacids;55686Da
      SUBUNIT:InteractswithCENTG1isoform2(PIKE-A)inthepresenceofguaninenucleotides.TheC-terminusinteractswithCCDC88A/GRDN.InteractswithAKTIP.
      SUBCELLULARLOCATION:Cytoplasm.Nucleus.Note=Nucleusafteractivationbyintegrin-linkedproteinkinase1(ILK1).
      TISSUESPECIFICITY:Inallhumancelltypessofaranalyzed.
      DOMAIN:SwissProt:P31749BindingofthePHdomaintothephosphatidylinositol3-kinasealpha(PI(3)K)resultsinitstargetingtotheplasmamembrane.
      PTM:PhosphorylationonThr-308,Ser-473andTyr-474isrequiredforfullactivity.Ser-473phosphorylationbytheRictor-mTorcomplexfavorsThr-308phosphorylationbyPDPK1.Ser-473phosphorylationisenhancedbyinteractionwithCENTG1isoform2(PIKE-A).
      SIMILARITY:Belongstotheproteinkinasesuperfamily.AGCSer/Thrproteinkinasefamily.RACsubfamily.&Contains1AGC-kinaseC-terminaldomain.&Contains1PHdomain.&Contains1proteinkinasedomain.
      MolecularWeight60kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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