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avanti polar lipids/22:0 Trehalose/25mg/890808P-25mg
  • avanti polar lipids/22:0 Trehalose/25mg/890808P-25mg

avanti polar lipids/22:0 Trehalose/25mg/890808P-25mg

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    • 890808 | 22:0 Trehalose

      D-(+)-trehalose 6,6"-dibehenate

      22:0 Trehalose
      Info

      22:0 Trehalose

      D-(+)-trehalose 6,6"-dibehenate

      Incorporation of the glycolipid trehalose 6,6"-dibehenate (TDB) into cationic liposomes composed of the quaternary ammonium compound dimethyldioctadecylammonium (DDA) produce an adjuvant system which induces a powerful cell-mediated immune response and a strong antibody response, desirable for a high number of disease targets.

      Data
      Hygroscopic
      No
      Light Sensitive
      No
      Molecular Formula
      C56H106O13
      Percent Composition
      C 68.12%, H 10.82%, O 21.06%
      Purity
      >99%
      Stability
      1 Years
      Storage Temperature
      -20°C
      CAS Number
      66758-35-8 CAS Registry Number is a Registered Trademark of the American Chemical Society
      FormulaWeight
      987.433
      Exact Mass
      986.763
      Synonyms
      TDB6,6'-didocosanoyl-α,α'-trehalose
      Downloads
      • ChemDraw File
      • 3D Structure
      • Structure
      • Brochure
      • Safety Data Sheet
      References

      Teng X, Tian M, Li J, Tan S, Yuan X, Yu Q, Jing Y, Zhang Z, Yue T, Zhou L, Fan X. Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine. Hum Vaccin Immunother. 2015;11(6):1456-64. doi: 10.1080/21645515.2015.1037057. PMID: 25905680; PMCID: PMC4514263.

      PubMed ID: 25905680

      Rose F, Wern JE, Ingvarsson PT, van de Weert M, Andersen P, Follmann F, Foged C. Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach. J Control Release. 2015 Jul 28;210:48-57. doi: 10.1016/j.jconrel.2015.05.004. Epub 2015 May 6. PMID: 25957906.

      PubMed ID: 25957906

      Derrick SC, Yabe I, Morris S, Cowley S. Induction of Unconventional T Cells by a Mutant Mycobacterium bovis BCG Strain Formulated in Cationic Liposomes Correlates with Protection against Mycobacterium tuberculosis Infections of Immunocompromised Mice. Clin Vaccine Immunol. 2016 Jul 5;23(7):638-47. doi: 10.1128/CVI.00232-16. PMID: 27226281; PMCID: PMC4933783.

      PubMed ID: 27226281

      Larrouy-Maumus G, Layre E, Clark S, Prandi J, Rayner E, Lepore M, de Libero G, Williams A, Puzo G, Gilleron M. Protective efficacy of a lipid antigen vaccine in a guinea pig model of tuberculosis. Vaccine. 2017 Mar 7;35(10):1395-1402. doi: 10.1016/j.vaccine.2017.01.079. Epub 2017 Feb 9. PMID: 28190740.

      PubMed ID: 28190740

      Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, H?rtlova A, Uebel S, Bosmann M, Hofmann J, Büttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R. Macrophage phosphoproteome analysis reveals MINCLE-dependent and -independent mycobacterial cord factor signaling. Mol Cell Proteomics. 2019 Jan 11. pii: mcp.RA118.000929. doi: 10.1074/mcp.RA118.000929. [Epub ahead of print]

      PubMed ID: 30635358

      Fomsgaard, A., Karlsson, I., Gram, G., Schou, C., Tang, S., Bang, P., Kromann, I., Andersen, P., Andreasen, L.V. (2011) Development and preclinical safety evaluation of a new therapeutic HIV-1 vaccine based on 18 T-cell minimal epitope peptides applying a novel cationic adjuvant CAF01. Vaccine. 29:7067-74.

      PubMed ID: 21767590

      Nordly, P., Agger, E.M., Andersen, P., Nielsen, H.M., Foged, C. (2011) Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/TDB liposomes: physico-chemical characterization and induction of CD8+ T-cell responses in vivo. Pharm Res. 28:553-62.

      PubMed ID: 21042837

      Gram, G.J., Karlsson, I., Agger, E.M., Andersen, P., Fomsgaard, A. (2009) A novel liposome-based adjuvant CAF01 for induction of CD8(+) cytotoxic T-lymphocytes (CTL) to HIV-1 minimal CTL peptides in HLA-A*0201 transgenic mice. PLoS One. 4:e6950.

      PubMed ID: 19759892

      Davidsen, J., Rosenkrands, I., Christensen, D., Vangala, A., Kirby, D., Perrie, Y., Agger, E.M., Andersen, P. (2005) Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6"-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses. Biochim Biophys Acta. 1718:22-31.

      PubMed ID: 16321607
      Certificates of Analysis
      • Certificate of Analysis(Lot No. 890808P-25MG-A-017and 6351PJA017)
      • Certificate of Analysis(Lot No. 890808P-5MG-A-017and 6351PHA017)
      • Certificate of Analysis(Lot No. 890808P-25MG-B-017and 6351PJB017)
      • Certificate of Analysis(Lot No. 890808P-5MG-B-017and 6351PHB017)
      • Certificate of Analysis(Lot No. 890808P-5MG-C-017and 6351PHC017)
      • Certificate of Analysis(Lot No. 890808P-25MG-C-017and 6351PJC017)
      • Certificate of Analysis(Lot No. 890808P-5MG-D-017and 6351PHD017)
      • Certificate of Analysis(Lot No. 890808P-5MG-E-017and 6351PHE017)
      • Certificate of Analysis(Lot No. 890808P-5MG-F-017and 6351PHF017)
      • Certificate of Analysis(Lot No. 890808P-25MG-D-017and 6351PJD017)
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