Description:REP1isthecomponentAoftheRABgeranylgeranyltransferaseholoenzyme.Inthedimericholoenzyme,thissubunitbindsunprenylatedRabGTPasesandthenpresentsthemtothecatalyticRabGGTasesubunitforthegeranylgeranyltransferreaction.Mutationsinthisproteinareacauseofatypeofretinaldegeneration,calledchoroideremia.Alternativenames:CHM,choroideraemiaprotein,DXS540,GGTA,HSD-32,RP1-93L7.1,rabescortprotein1,RabgeranylgeranyltransferasecomponentA,REP-1,TCDantibody.
Form:Polyclonalantibodysuppliedasa200μl(3mg/ml)aliquotinPBS,20%glyceroland0.05%sodiumazide.Thisantibodyisepitope-affinitypurifiedfromgoatantiserum.
Immunogen:Purifiedrecombinantpeptidederivedfromwithinresidues1-80aaattheN-terminusofratRep1producedinE.coli.
Specificity:DetectsendogeneousRep1andintransfectedcellsbyWesternblot.
Reactivity:Reactsagainsthuman,rat,mouse,canineandmonkeyproteins.
Storage:Storeat-20Cforlongtermstorage.Storeat2-8Cforuptoonemonth.
Specialinstructions:Avoidfreeze/thawcycles.