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Millipore/AB1847 | Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop/AB1847/100 µg
  • Millipore/AB1847 | Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop/AB1847/100 µg

Millipore/AB1847 | Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop/AB1847/100 µg

價(jià)格: ¥4068.00 市場價(jià): 6780.00

貨號: AB1847
品牌: Millipore
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    • Description
      CatalogueNumberAB1847
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-C-X-CChemokineReceptor4Antibody,extracellularloop
      AlternateNames
      • CD184
      • CXCR4
      ProductInformation
      FormatPurified
      PresentationPurifiedIgGinPBScontaining0.02%sodiumazide.
      StorageandShippingInformation
      StorageConditionsCanberefrigeratedat2-8°Cinundilutedaliquotsforupto12monthsfromdateofreceipt.
      Applications
      ApplicationAnti-C-X-CChemokineReceptor4Antibody,extracellularloopdetectslevelofC-X-CChemokineReceptor4&hasbeenpublished&validatedforuseinWB.
      KeyApplications
      • WesternBlotting
      ApplicationNotesWesternblot:1:500-1000

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenExtracellularlooppeptideofhumanCXCR4(Bersonetal.1996;Leotscheretal.1994).
      Epitopeextracellularloop
      HostRabbit
      SpecificitySomeGprotein-coupledreceptorsincludingCCR5,CXCR4,CCR3,CCR2bandCCR8inthechemokinereceptorfamily,andfournewhumanmoleculesGPR15,STRL33,GPR1andV28wererecentlyidentifiedasHIVcoreceptors(Nimitrov1997).Amongthem,CXCR4(fusin,LESTRorHUMSTR)isaprinciplecoreceptorforT-celltropicstrainsofHIV-1fusionandentryofhumanwhitebloodcells(Fengetal.1996;Bersonetal.1996).CXCR4isalsorequiredfortheinfectionbydual-tropicstrainsofHIV-1andmediatesCD-4independentinfectionbyHIV-2(Doranzetal.1996;Endresetal.1996).Thea-chemokineSDF-1istheligandforCXCR4andpreventsinfectionbyT-tropicHIV-1(Bleuletal.1996;Oberlinetal.1996).CXCR4associateswiththesurfaceCD4-gp120complexbeforeHIVenterstargetcells(Laphametal.1996).CXCR4messengerRNAlevelscorrelatedwithHIV-1permissivenessindiversehumancelltypes(Fengetal.1996).AntibodiestoCXCR4blockHIV-1andHIV-2fusionandinfectionofhumantargetcells(Fengetal.1996;Endresetal.1996;Brelotetal.1997).Theamino-terminaldomainandthesecondextracellularloopofCXCR4serveasHIVbindingsites(Brelotetal.1997;Luetal.1997).
      SpeciesReactivity
      • Human
      • Mouse
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesaCXCchemokinereceptorspecificforstromalcell-derivedfactor-1.Theproteinhas7transmembraneregionsandislocatedonthecellsurface.ItactswiththeCD4proteintosupportHIVentryintocellsandisalsohighlyexpressedinbreastcancercells.MutationsinthisgenehavebeenassociatedwithWHIM(warts,hypogammaglobulinemia,infections,andmyelokathexis)syndrome.Alternatetranscriptionalsplicevariants,encodingdifferentisoforms,havebeencharacterized.
      GeneSymbol
      • CXCR4
      • WHIM
      • NPY3R
      • NPYY3R
      • FB22
      • LAP3
      • Fusin
      • CXCR-4
      • LCR1
      • NPYR
      • HM89
      • fusin
      • HSY3RR
      • CXC-R4
      • NPYY3
      • NPYRL
      • D2S201E
      • CD184
      • LESTR
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P61073#ReceptorfortheC-X-CchemokineCXCL12/SDF-1.Transducesasignalbyincreasingtheintracellularcalciumionslevel.Involvedinhaematopoiesisandincardiacventricularseptumformation.Playsalsoanessentialroleinvascularizationofthegastrointestinaltract,probablybyregulatingvascularbranchingand/orremodelingprocessesinendothelialcells.Couldbeinvolvedincerebellardevelopment.IntheCNS,couldmediatehippocampal-neuronsurvival.Actsasacoreceptor(CD4beingtheprimaryreceptor)forHIV-1X4isolatesandasaprimaryreceptorforsomeHIV-2isolates.PromotesEnv-mediatedfusionofthevirus.
      SIZE:352aminoacids;39746Da
      SUBUNIT:InteractswithHIV-1surfaceproteingp120andTat.
      SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein.
      TISSUESPECIFICITY:Expressedinnumeroustissues,suchasperipheralbloodleukocytes,spleen,thymus,spinalcord,heart,placenta,lung,liver,skeletalmuscle,kidney,pancreas,cerebellum,cerebralcortexandmedulla(inmicrogliaaswellasinastrocytes),brainmicrovascular,coronaryarteryandumbilicalcordendothelialcells.Isoform1ispredominantinalltissuestested.
      DOMAIN:SwissProt:P61073Theamino-terminusiscriticalforligandbinding.ResiduesinallfourextracellularregionscontributetoHIV-1coreceptoractivity.
      PTM:Sulfated.
      DISEASE:SwissProt:P61073#DefectsinCXCR4areacauseofWHIMsyndrome[MIM:193670];alsocalledwarts,hypogammaglobulinemia,infections,andmyelokathexis.WHIMsyndromeisanimmunodeficiencydiseasecharacterizedbyneutropenia,hypogammaglobulinemiaandextensivehumanpapillomavirus(HPV)infection.Despitetheperipheralneutropenia,bonemarrowaspiratesfromaffectedindividualscontainabundantmaturemyeloidcells,aconditiontermedmyelokathexis.
      SIMILARITY:BelongstotheG-proteincoupledreceptor1family.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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