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Millipore/AB1922 | Anti-Integrin β4 Antibody/AB1922/100 µL
  • Millipore/AB1922 | Anti-Integrin β4 Antibody/AB1922/100 µL

Millipore/AB1922 | Anti-Integrin β4 Antibody/AB1922/100 µL

價格: ￥4068.00 市場價: 6780.00
貨號: AB1922
品牌: Millipore
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    • Description
      CatalogueNumberAB1922
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-Integrinβ4Antibody
      AlternateNames
      • CD104
      ProductInformation
      FormatSerum
      PresentationWholerabbitserum.Liquid,with0.02%sodiumazide.
      StorageandShippingInformation
      StorageConditionsTheundilutedantibodysolutionisstableforapproximately6monthswhenstored-20°C.
      Applications
      ApplicationAnti-Integrinβ4AntibodyisanantibodyagainstIntegrinβ4foruseinIP,IH.
      KeyApplications
      • Immunoprecipitation
      • Immunohistochemistry
      ApplicationNotesImmunoprecipitationfromlabeledcellextracts:5μLofserumissufficienttoprecipitatealpha6beta4from1-2x10E6cells.Insomecasesimmunoprecipitationfrom35Smethioninelabeledcellsresultsintwobandsof95and55kDaofunknownorigininadditiontothe200kDaand140kDabandscorrespondingtobeta4andalpha6.

      Immunohistochemistry:5μg/mL.Seeprotocolbelow.

      Optimalworkingdilutionsmustbedeterminedbytheenduser.



      SuggestedProtocolforImmunohistochemical:

      1.Fixcryostatsectionswitha1:1chloroform-acetonemixturefor10minutesatroomtemperature.

      2.AirDry.

      3.Washwith2mLof1xPBS.

      4.Add200μLoffirstantibody(5μg/mL)toeachslide.Incubatefor1houratroomtemperatureinahumiditychamber.

      5.Washwith5mLof1xPBS.

      6.Addappropriatelydilutedanti-rabbitsecondaryantibodyconjugateandincubatefor1hourinahumiditychamber

      7.Washwith5mLof1xPBS.

      8.Add200μLofdevelopmentsolution(containingDABorothersubstratedependingonthesecondaryantibody)andincubateatroomtemperatureforthenecessarytimetodevelopthedarkcolor.Followthereactionwithamicroscope,toestablishthecorrectcolorintensity.

      9.Blockthereactionbywashingwith2mLof1xPBS.

      10.Counterstainwithhematoxylinasdesired.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidederivedfromtheCOOHterminalsequence(cytoplasmicdomain)ofthehumanβ4integrinsubunit(Tamuraetal.1990).ThesequenceusedisNH2-(K)GTLSTHMDQQFFQT-amide.Thelysine(K)isnotintheβ4sequenceandwasaddedtoconjugatethepeptid
      HostRabbit
      SpecificitySpecificforbeta4integrinasdeterminedbyimmunoprecipitation.Theepitoperecognizedisonthecytoplasmicdomainoftheproteinandisthusintracellular.Nocross-reactivitytootherintegrinbsubunits.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryIntegrinsareheterodimerscomprisedofalphaandbetasubunits,thatarenoncovalentlyassociatedtransmembraneglycoproteinreceptors.Differentcombinationsofalphaandbetapolypeptidesformcomplexesthatvaryintheirligand-bindingspecificities.Integrinsmediatecell-matrixorcell-celladhesion,andtransducedsignalsthatregulategeneexpressionandcellgrowth.Thisgeneencodestheintegrinbeta4subunit,areceptorforthelaminins.Thissubunittendstoassociatewithalpha6subunitandislikelytoplayapivotalroleinthebiologyofinvasivecarcinoma.Mutationsinthisgeneareassociatedwithepidermolysisbullosawithpyloricatresia.Multiplealternativelysplicedtranscriptvariantsencodingdistinctisoformshavebeenfoundforthisgene.
      GeneSymbol
      • ITGB4
      • CD104
      • GP150
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P16144#Integrinalpha-6/beta-4isareceptorforlaminin.Itplaysacriticalstructuralroleinthehemidesmosomeofepithelialcells.
      SIZE:1822aminoacids;202151Da
      SUBUNIT:Heterodimerofanalphaandabetasubunit.Beta-4associateswithalpha-6.
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      TISSUESPECIFICITY:Integrinalpha-6/beta-4ispredominantlyexpressedbyepithelia.Isoformbeta-4Disalsoexpressedincolonandplacenta.Isoformbeta-4Eisalsoexpressedinepidermis,lung,duodenum,heart,spleenandstomach.
      DOMAIN:SwissProt:P16144Thefibronectintype-III-likedomainsbindBPAG1andplectinandprobablyalsorecruitBP230.
      DISEASE:SwissProt:P16144#DefectsinITGB4areacauseofepidermolysisbullosaletaliswithpyloricatresia(EB-PA)[MIM:226730];alsoknownasjunctionalepidermolysisbullosawithpyloricatresia(PA-JEB)oraplasiacutiscongenitawithgastrointestinalatresia.EB-PAischaracterizedbymucocutaneousfragilityandgastrointestinalatresia,whichmostcommonlyaffectsthepylorus.&DefectsinITGB4areacauseofgeneralizedatrophicbenignepidermolysisbullosa(GABEB)[MIM:226650].Thisnonlethalformofjunctionalepidermolysisbullosaischaracterizedbylife-longblisteringoftheskin,associatedwithhairandtoothabnormalities.
      SIMILARITY:Belongstotheintegrinbetachainfamily.&Contains1Calx-betadomain.&Contains4fibronectintype-IIIdomains.&Contains1VWFAdomain.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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