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Millipore/AB2047 | Anti-Fibronectin Antibody/AB2047/100 µg
  • Millipore/AB2047 | Anti-Fibronectin Antibody/AB2047/100 µg

Millipore/AB2047 | Anti-Fibronectin Antibody/AB2047/100 µg

價(jià)格: ￥4068.00 市場價(jià): 6780.00
貨號(hào): AB2047
品牌: Millipore
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    • Description
      CatalogueNumberAB2047
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-FibronectinAntibody
      BackgroundInformationFibronectin(FN)isanextracellularadhesionmoleculeanditisinvolvedinmanycellularprocesses,includingtissuerepair,embryogenesis,bloodclotting,andcellmigration/adhesion.

      Fibronectinexistsintwomainforms:1)asaninsolubleglycoproteindimerthatservesasalinkerintheECM(extracellularmatrix),and;2)asasolubledisulphidelinkeddimerfoundintheplasma(plasmaFN).Theplasmaformissynthesizedbyhepatocytes,andtheECMformismadebyfibroblasts,chondrocytes,endothelialcells,macrophages,aswellascertainepithelialcells.

      Fibronectinsometimesservesasageneralcelladhesionmoleculebyanchoringcellstocollagenorproteoglycansubstrates.FNalsocanservetoorganizecellularinteractionwiththeECMbybindingtodifferentcomponentsoftheextracellularmatrixandtomembrane-boundFNreceptorsoncellsurfaces.Theimportanceoffibronectinincellmigrationeventsduringembryogenesishasbeendocumentedinseveralcontexts,e.g.:1)mesodermalcellmigrationduringgastrulationcanbeblockedbyinjectionofArg-Gly-Asp(RGD)tripeptidesthatblockcellularFNreceptors(integrins);2)injectionofanti-FNantibodiesintochickembryosblocksmigrationofprecardiaccellstotheembryonicmidline,and;3)thepatternsofFNdepositionindevelopingvertebratelimbsdeterminesthepatternsofprecartilagecelladhesiontotheECM,therebyspecifyinglimb-specificpatternsofchondrogenesis.{D.Marcey,http://www.clunet.edu/BioDev/omm/fibro/frames/fibrotxt.htm}.
      ProductInformation
      FormatPurified
      PresentationProteinGaffinitypurifiedIgGfractionat1.0mg/mLinliquidPBS(0.01Mphosphate,0.09MNaCl)pH7.2withnopreservatives.
      StorageandShippingInformation
      StorageConditionsMaintainfrozenat-20°Cforupto12monthsfromdateofreceipt.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationAnti-FibronectinAntibodydetectslevelofFibronectin&hasbeenpublished&validatedforuseinELISA,IF,RIA,WB,IH(P).
      KeyApplications
      • ELISA
      • Immunofluorescence
      • RADIoimmunoassay
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      ApplicationNotesImmunohistochemistry:1:80dilutionforimmunofluorescentstainingoffreshfrozenbovineskinandlivertissues.Acetoneormethyl-carnoyfixationisalsoreactive.

      Immunohistochemistryonparaffinembeddedtissuesrequireslightfixationin2%PFA,4%formalin(lessthan90minutes),acetoneormethyl-carnoyfixation;traditionalformalinfixationisnotrecommended.AntigenretrievalisHIERcitratebuffer;detectionisviaenhancedenzymaticmethodsonly.

      Immunoblotting:1:1000of2%deoxycholate+10%SDS,6Mureaextractedbovinecellcultures(Kinsella,2000).Antibodydemonstatestheappropriatetwinbandsat~220kDa.

      Radioimmunoassay

      ELISA

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenFibronectinextractedandpurifiedfrombovineplasma.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityAntibodyreactswithbovinefibronectin,anddemonstratescross-reactivityoflessthan0.1%withbovinecollagenstypesI,III,IVbyRIAat1:10,000dilution.
      SpeciesReactivity
      • Bovine
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesfibronectin,aglycoproteinpresentinasolubledimericforminplasma,andinadimericormultimericformatthecellsurfaceandinextracellularmatrix.Fibronectinisinvolvedincelladhesionandmigrationprocessesincludingembryogenesis,woundhealing,bloodcoagulation,hostdefense,andmetastasis.Thegenehasthreeregionssubjecttoalternativesplicing,withthepotentialtoproduce20differenttranscriptvariants.However,thefull-lengthnatureofsomevariantshasnotbeendetermined.
      GeneSymbol
      • FN1
      • DKFZp686O13149
      • DKFZp686H0342
      • DKFZp686I1370
      • MSF
      • FN
      • CIG
      • DKFZp686F10164
      • LETS
      • FINC
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P02751#Fibronectinsbindcellsurfacesandvariouscompoundsincludingcollagen,fibrin,heparin,DNA,andactin.Fibronectinsareinvolvedincelladhesion,cellmotility,opsonization,woundhealing,andmaintenanceofcellshape.InteractionwithTNRmediatesinhibitionofcelladhesionandneuriteoutgrowth(Bysimilarity).
      SIZE:2386aminoacids;262607Da
      SUBUNIT:Mostlyheterodimersormultimersofalternativelysplicedvariants,connectedby2disulfidebondsnearthecarboxylends;toalesserextenthomodimers.InteractswithFBLN1,AMBP,TNR,LGALS3BPandCOL13A1.
      SUBCELLULARLOCATION:Secreted,extracellularspace,extracellularmatrix.
      TISSUESPECIFICITY:PlasmaFN(solubledimericform)issecretedbyhepatocytes.CellularFN(dimericorcross-linkedmultimericforms),madebyfibroblasts,epithelialandothercelltypes,isdepositedasfibrilsintheextracellularmatrix.Ugl-Y1,Ugl-Y2andUgl-Y3arefoundinurine.DEVELOPMENTALSTAGE:Ugl-Y1,Ugl-Y2andUgl-Y3arepresentintheurinefrom0to17yearsofage.
      PTM:Sulfated.
      SIMILARITY:SwissProt:P02751##Contains12fibronectintype-Idomains.&Contains2fibronectintype-IIdomains.&Contains16fibronectintype-IIIdomains.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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