Immunogen | KLH-conjugatedlinearpeptidecorrespondingtomouseTbr2. |
Epitope | InternalDomain |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | ThisantibodyrecognizesTbr2. |
SpeciesReactivity | |
SpeciesReactivityNote | Proventoreactwithhumanandmouse. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
GeneSymbol | - eomes
- TBR2
- eomesodermin
- tbr1
|
PurificationMethod | AffinityPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:Functionsasatranscriptionalactivatorplayingacrucialroleduringdevelopment.Functionsintrophoblastdifferentiationandlateringastrulation,regulatingbothmesodermdelaminationandendodermspecification.PlaysaroleinbraindevelopmentbeingrequiredforthespecificationandtheproliferationoftheintermediateProgenitorcellsandtheirprogenyinthecerebralcortex.AlsoinvolvedinthedifferentiationofCD8+T-cellsduringimmuneresponseregulatingtheexpressionoflyticeffectorgenes.
SUBCELLULARLOCATION:NucleusProbable.
TISSUESPECIFICTY:ExpressedinCD8+T-cells.
DEVELOPMENTALSTAGE:Originallyexpressedinthetrophoectodermoftheblastocystandlaterintheextra-embryonicectodermoftheearlypost-implantationembryo.Intheembryoproper,expressedintheposteriorpartoftheepIBLast.Duringgastrulation,extendsdistallyintotheprimitivestreakandnascentmesoderm.Alsoexpressedinthedevelopingforebrainandtheolfactorylobes.ExpressedatE12.5andE14.5intheforebrain.
INDUCTION:Up-regulatedinCD8+T-cellsuponactivation.
DISRUPTIONPHENOTYPE:Embryoniclethalduetoperi-implantationdefects.Mutantembryosarrestsoonafterimplantationandfailtoformorganizedembryonicorextraembryonicstructures.Conditionalmutants,withexpressionabrogatedintheinnercellmassofembryosfromearlyimplantationstagesonward,displaygastrulationdefects.
SEQUENCESIMLARITIES:Contains1T-boxDNA-bindingdomain. |
MolecularWeight | N/A |