Immunogen | Peptidecorrespondingtoaa2-17ofmousecaspase-12. |
Epitope | N-terminus |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | Antibodyrecognizescaspase12pro-proteininmouseextractsofnormalandapoptoticcells.Caspase12ispredictedtohavealarge>120aalongprodomainregion.Thusthisantibodyrecognizesonlytheproformsoftheenzymeandnottheactivesubunits.Uncleaved(proform)caspase12isprominentlydetectedinmanytissues.Activeformsaredifficulttodetectexpectintransfectcellsystems.{Kalai,Metal(2003)162:457-467}. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneSummary | CaspasesarecysteineproteasesthatcleaveC-terminalasparticacidresiduesontheirsubstratemolecules.Thisgene,CASP12,ismosthighlyrelatedtomembersoftheICEsubfamilyofcaspasesthatprocessinflammatorycytokines.Inrodents,thehomologofthisgenemediatesapoptosisinresponsetoendoplasmicreticulumstress.However,inhumansthisgenecontainsapolymorphismforthepresenceorabsenceofaprematurestopcodon.Themajorityofhumanindividualshavetheprematurestopcodonandproduceatruncatednon-functionalprotein.Theread-throughcodonoccursprimarilyinindividualsofAfricandescentandcarriershaveendotoxinhypo-responsivenessandanincreasedsusceptibilitytoseveresepsis. |
GeneSymbol | - CASP12
- Caspase-12.
- CASP12P1
|
UniProtNumber | |
UniProtSummary | SIZE:341aminoacids;38907Da |