Immunogen | Syntheticpeptidecorrespondingtoaminoacids320-341ofhumanArp2.Theimmunogensequenceis100%identicalinmouse,rat,Xenopus,andchicken. |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | RecognizesArp2(Actin-relatedprotein2).Arp2belongstotheArp2/3complex,which,whenstimulatedbyWASp/Scarproteins,nucleatesactinpolymerizationfromthesidesofpre-existingactinfilaments.TheevolutionarilyconservedArp2/3complexincludesArp2,Apr3,p41-Arc,p34-Arc,p21-Arc,p20-Arcandp16-Arc. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thespecificfunctionofthisgenehasnotyetbeendetermined;however,theproteinitencodesisknowntobeamajorconstituentoftheARP2/3complex.Thiscomplexislocatedatthecellsurfaceandisessentialtocellshapeandmotilitythroughlamellipodialactinassemblyandprotrusion.Twotranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene. |
GeneSymbol | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P61160#FunctionsasATP-bindingcomponentoftheArp2/3complexwhichisinvolvedinregulationofactinpolymerizationandtogetherwithanactivatingnucleation-promotingfactor(NPF)mediatestheformationofbranchedactinnetworks.Seemstocontactthepointedendofthedaughteractinfilament. SIZE:394aminoacids;44761Da SUBUNIT:ComponentoftheArp2/3complexcomposedofARP2,ARP3,ARPC1B/p41-ARC,ARPC2/p34-ARC,ARPC3/p21-ARC,ARPC4/p20-ARCandARPC5/p16-ARC. SUBCELLULARLOCATION:Cytoplasm,Cytoskeleton. SIMILARITY:SwissProt:P61160##Belongstotheactinfamily.ARP2subfamily. |