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Millipore/AB5320C3 | Anti-NG2 Chondroitin Sulfate Proteoglycan, Cy3 Conjugate Antibody/AB5320C3/100 µL
  • Millipore/AB5320C3 | Anti-NG2 Chondroitin Sulfate Proteoglycan, Cy3 Conjugate Antibody/AB5320C3/100 µL

Millipore/AB5320C3 | Anti-NG2 Chondroitin Sulfate Proteoglycan, Cy3 Conjugate Antibody/AB5320C3/100 µL

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貨號(hào): AB5320C3
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    • Description
      CatalogueNumberAB5320C3
      DescriptionAnti-NG2ChondroitinSulfateProteoglycan,Cy3ConjugateAntibody
      AlternateNames
      • Chondroitinsulfateproteoglycan4
      • ChondroitinsulfateproteoglycanNG2
      • Melanomachondroitinsulfateproteoglycan
      • Melanoma-associatedchondroitinsulfateproteoglycan
      BackgroundInformationNG2isahighmolecularweight,integralmembranechondroitinsulfateproteoglycan.Itisfoundonthesurfacesofanunusualclassofglialcellswithinthedevelopingandmaturecentralnervoussystemthathavethepropertiesofoligodendrocyteprecursorcells(i.e.,O-2AProgenitorcells).NG2isalsofoundonthesurfacesofchondroblasts,proliferatingcapillaryendothelialcells,somehumanmelanomacelllines,andonleukemicblastsinchildhoodacutelymphoblasticleukemia.TheNG2proteoglycanislikelytoplayaroleinregulationofcellmotility,axonoutgrowthandthecellularresponsestoplatelet-derivedgrowthfactor.
      ProductInformation
      FormatCy3
      Control
      • Ratoligodendrocyteprecursorcells
      PresentationPurifiedrabbitpolyclonalconjugatedtoCy3inPBSwith0.1%sodiumazideand15mg/mLBSA.
      StorageandShippingInformation
      StorageConditionsMaintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.
      Applications
      ApplicationAnti-NG2ChondroitinSulfateProteoglycan,Cy3ConjugateAntibodyisanantibodyagainstNG2ChondroitinSulfateProteoglycanforuseinICC&IHC.
      KeyApplications
      • Immunocytochemistry
      • Immunohistochemistry
      BIOLOGicalInformation
      ImmunogenImmunoaffinitypurifiedNG2ChondroitinSulfateProteoglycanfromrat
      HostRabbit
      SpecificityThisantibodyidentifiestheintactproteoglycanandcoreproteinbyWBandELISA.Whenoligodendrocyteprecursorcells(i.e.O-2Aprogenitorcells)arestainedalive,thestainappearsasclustersonthecellsurface.Thisantibodydoesnotstaindifferentiatedoligodendrocyteswell.
      IsotypeIgG
      SpeciesReactivity
      • Rat
      • Mouse
      • Human
      • Monkey
      SpeciesReactivityNoteTestedandpassedonRat.PredictedonMouse,Human,Monkeybasedon100%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryAhumanmelanoma-associatedchondroitinsulfateproteoglycanplaysaroleinstABIlizingcell-substratuminteractionsduringearlyeventsofmelanomacellspreADIngonendothelialbasementmembranes.CSPG4representsanintegralmembranechondroitinsulfateproteoglycanexpressedbyhumanmalignantmelanomacells.
      GeneSymbol
      • CSPG4
      • MCSP
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsabilitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreadingbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades.

      SIZE:2322aminoacids;250497Da

      SUBUNIT:InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2(Bysimilarity).InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16.

      SUBCELLULARLOCATION:Apicalcellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Note=LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity).

      TISSUESPECIFICITY:Detectedonlyinmalignantmelanomacells.

      PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation(Bysimilarity).InvolvedininteractionwithMMP16andITGA4.&PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility(Bysimilarity).

      SIMILARITY:Contains15CSPG(NG2)repeats.&Contains2lamininG-likedomains.

      MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells
      MolecularWeightTheunconjugatedparentantibody(Cat.No.AB5320)hasanobservedmolecularweightat~270-300kDa.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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