Immunogen | SyntheticpeptidefromratVGLUT3protein. |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | GuineaPig |
Specificity | RecognizesVesicularGlutamateTransporter3(VGLUT3).Theantiserumhasbeentestedontissuesectionsfromtheratcentralnervoussystem(CNS)usingimmunofluorescencehistochemistry.ThestainingpatternpresentincellbodiesobtainedwiththeguineapigVGLUT3antiserumisinagreementwiththedescribedexpressionpatternofVGLUT3mRNAThestainingpatternobtainedinbothcellbodiesandnervefiberswiththeguineapigVGLUT3antiserumcoincideswiththedescribeddistributionofVGLUT3immunoreactivityobtainedwithotherVGLUT3antisera(Fremeau,2002;Gras,2002;Sch?fer,2002).PreabsorptionoftheVGLUT3antiserumwiththeimmunogenpeptide(CatalognumberAG320)eliminatesallimmunostaining. |
SpeciesReactivity | |
SpeciesReactivityNote | Rat.Itisexpectedthattheantibodymayalsoreactwithmousebasedonsequencehomology(85%).Otherspecieshavenotyetbeentested. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
GeneSymbol | - VGLUT3
- VGluT3
- SLC17A8
- DFNA25
|
PurificationMethod | Unpurified |
UniProtNumber | |
UniProtSummary | FUNCTION:Mediatestheuptakeofglutamateintosynapticvesiclesatpresynapticnerveterminalsofexcitatoryneuralcells.Mayalsomediatethetransportofinorganicphosphate. SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane(Bysimilarity).Membrane;Multi-passmembraneprotein(Potential).Celljunction,synapse,synaptosome(Bysimilarity). TISSUESPECIFICITY:Expressedinamygdala,cerebellum,hippocampus,medulla,spinalcordandthalamus. SIMILARITY:Belongstothemajorfacilitatorsuperfamily.Sodium/anioncotransporterfamily.VGLUTsubfamily. SIZE:589aminoacids;64991Da |
MolecularWeight | ~65kDa |