Immunogen | Syntheticpeptidethatcorrespondstoaminoacids325-342oftheC-terminusofthehumanMSRtypeI. |
Host | Goat |
Specificity | SpecificforhumanmacrophagescavengerreceptortypeI(MSRtypeI).Thisantibodyimmunolabelsamyloidplaquesinformalin-fixedparaffinsectionsfromAlzheimer"sDisease(AD)brain. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | ThisgeneencodestheclassAmacrophagescavengerreceptors,whichincludethreedifferenttypes(1,2,3)generatedbyalternativesplicingofthisgene.Thesereceptorsorisoformsaremacrophage-specifictrimericintegralmembraneglycoproteinsandhavebeenimplicatedinmanymacrophage-associatedphysiologicalandpathologicalprocessesincludingatherosclerosis,Alzheimer"sdisease,andhostdefense.Theisoformstype1andtype2arefunctionalreceptorsandareabletomediatetheendocytosisofmodifiedlowdensitylipoproteins(LDLs).Theisoformtype3doesnotinternalizemodifiedLDL(acetyl-LDL)despitehavingthedomainshowntomediatethisfunctioninthetypes1and2isoforms.Ithasanalteredintracellularprocessingandistrappedwithintheendoplasmicreticulum,makingitunabletoperformendocytosis.Theisoformtype3caninhibitthefunctionofisoformstype1andtype2whenco-expressed,indicatingadominantnegativeeffectandsuggestingamechanismforregulationofscavengerreceptoractivityinmacrophages. |
GeneSymbol | - MSR1
- SR-A
- SCARA1
- phSR2
- phSR1
- CD204
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P21757#Membraneglycoproteinsimplicatedinthepathologicdepositionofcholesterolinarterialwallsduringatherogenesis.Twotypesofreceptorsubunitsexist.Thesereceptorsmediatetheendocytosisofadiversegroupofmacromolecules,includingmodifiedlowdensitylipoproteins(LDL). SIZE:451aminoacids;49762Da SUBUNIT:Homotrimer. SUBCELLULARLOCATION:Membrane;Single-passtypeIImembraneprotein. SIMILARITY:SwissProt:P21757##Contains1collagen-likedomain.&Contains1SRCRdomain. |