Immunogen | Peptidecorrespondingtoaminoacids1-19fromratSynaptotagminI(Accession#P21107). |
Epitope | luminalpart |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | RecognizesSynaptotagminI,luminalpart.Theepitopedoesnotsharehomologywithanyotherknownproteins.
SPECIESREACTIVITIES:Itisexpectedthattheantibodywillalsorecognizehuman.Otherspecieshavenotbeentested. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | ThesynaptotagminsareintegralmembraneproteinsofsynapticvesiclesthoughttoserveasCa(2+)sensorsintheprocessofvesiculartraffickingandexocytosis.CalciumbindingtosynaptotagminIparticipatesintriggeringneurotransmitterreleaseatthesynapse(Fernandez-Chaconetal.,2001[PubMed11242035]).[suppliedbyOMIM] |
GeneSymbol | - SYT1
- DKFZp781D2042
- SVP65
- SytI
- SYT
- p65
- P65
- Synaptotagmin-1
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P21579#Mayhavearegulatoryroleinthemembraneinteractionsduringtraffickingofsynapticvesiclesattheactivezoneofthesynapse.Itbindsacidicphospholipidswithaspecificitythatrequiresthepresenceofbothanacidicheadgroupandadiacylbackbone.ACa(2+)-dependentinteractionbetweensynaptotagminandputativereceptorsforactivatedproteinkinaseChasalsobeenreported.ItcanbindtoatleastthreeadditionalproteinsinaCa(2+)-independentmanner;theseareneurexins,syntaxinandAP2. COFACTOR:Binds3calciumionspersubunit.TheionsareboundtotheC2domains(Bysimilarity). SIZE:422aminoacids;47573Da SUBUNIT:Homotetramer(Probable).InteractswithSTN2,SV2A,SV2B,SV2CandRIMS1.FormsacomplexwithSV2B,syntaxin1andSNAP25(Bysimilarity). SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesicle.Cytoplasmicvesicle,secretoryvesicle,chromaffingranule.Note=Synapticvesiclesandchromaffingranules. DOMAIN:SwissProt:P21579ThefirstC2domainmediatesCa(2+)-dependentphospholipidbinding.&ThesecondC2domainmediatesinteractionwithSV2AandSTN2(Bysimilarity). SIMILARITY:Belongstothesynaptotagminfamily.&Contains2C2domains. |