Immunogen | GSTfusionproteincorrespondingtoacytoplasmicpartofratSyntaxin1A(AccessionnumberP32851)(Bennetetal.1992;Inoue&Akagawa1992). |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | RecognizesSyntaxin1AandSyntaxin1B.Theepitopedoesnotsharehomologywithanyotherknownproteins. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Synapticvesiclesstoreneurotransmittersthatarereleasedduringcalcium-regulatedexocytosis.Thespecificityofneurotransmitterreleaserequiresthelocalizationofbothsynapticvesiclesandcalciumchannelstothepresynapticactivezone.Syntaxinsfunctioninthisvesiclefusionprocess.SyntaxinsalsoserveasasubstrateforbotulinumneurotoxintypeC,ametalloproteasethatblocksexocytosisandhashighaffinityforamolecularcomplexthatincludesthealpha-latrotoxinreceptor(MIM600565)whichproducesexplosiveexocytosis(Zhangetal.,1995[PubMed7622072]).[suppliedbyOMIM] |
GeneSymbol | - STX1A
- HPC-1
- STX1
- Syntaxin-1A
- p35-1
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q16623#Potentiallyinvolvedindockingofsynapticvesiclesatpresynapticactivezones.Mayplayacriticalroleinneurotransmitterexocytosis. SIZE:288aminoacids;33023Da SUBUNIT:PartoftheSNAREcorecomplexcontainingSNAP25,VAMP2andSTX1A.ThiscomplexbindstoCPLX1.BindsSYTL4andSTXBP6.FoundinaternarycomplexwithSTX1AandSNAP25(Bysimilarity).FoundinacomplexwithVAMP8andSNAP23.InteractswithVAPAandSYBU. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeIVmembraneprotein.&Isoform2:Secreted(Probable). TISSUESPECIFICITY:Isoform1ishighlyexpressedinembryonicspinalchordandgangliaandinadultcerebellumandcerebralcortex.Isoform2isexpressedinheart,liver,fat,skeletalmuscle,kidneyandbrain. DISEASE:SwissProt:Q16623#HaploinsufficiencyofSTX1Amaybethecauseofcertaincardiovascularandmusculo-skeletalabnormalitiesobservedinWilliams-Beurensyndrome(WBS),araredevelopmentaldisorder.Itisacontiguousgenedeletionsyndromeinvolvinggenesfromchromosomeband7q11.23. SIMILARITY:SwissProt:Q16623##Belongstothesyntaxinfamily.&Contains1t-SNAREcoiled-coilhomologydomain. |