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Millipore/AB5864 | Anti-Myelin Basic Protein Antibody/AB5864/50 µL
  • Millipore/AB5864 | Anti-Myelin Basic Protein Antibody/AB5864/50 µL

Millipore/AB5864 | Anti-Myelin Basic Protein Antibody/AB5864/50 µL

價(jià)格: ￥4188.00 市場價(jià): 6980.00
貨號: AB5864
品牌: Millipore
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    • Description
      CatalogueNumberAB5864
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-MyelinBasicProteinAntibody
      AlternateNames
      • MBP
      ProductInformation
      FormatSerum
      Control
      • Braintissue
      PresentationRabbitSerum.Lyophilized,nopreservatives.Reconstitutewith50μLofsteriledistilledwater.Centrifugetoremoveanyresidue.
      StorageandShippingInformation
      StorageConditionsMaintainat-20to-70°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.Glycerol(1:1)canbeaddedforadditionalstABIlity.
      Applications
      ApplicationAnti-MyelinBasicProteinAntibodyisanantibodyagainstMyelinBasicProteinforuseinIH.
      KeyApplications
      • Immunohistochemistry
      ApplicationNotesImmunohistochemistry:1:2,000.Immunostainsmyelinbasicproteinofabnormalappearingoligodendrocyticprocessesandcellbodiesindemyelinatingareas.Theantibodyrecognizesonlyareasofmyelindegenerationwhentestedininjuredspinalcordandlesionedsciaticnerve.Italsostainsdiscretewhitematterinbrainofmultiplesystematrophy

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoaminoacids69-86oftheguineapigprotein.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizesMyelinBasicProteinindemyelinatednervetissues.Immunohistochemistryanalysisoflesionedratspinalcordshowsahighlevelofspecificityforthisantiserum.
      SpeciesReactivity
      • Human
      • Rat
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbytheclassicMBPgeneisamajorconstituentofthemyelinsheathofoligodendrocytesandSchwanncellsinthenervoussystem.However,MBP-relatedtranscriptsarealsopresentinthebonemarrowandtheimmunesystem.ThesemRNAsarisefromthelongMBPgene(otherwisecalled"Golli-MBP")thatcontains3additionalexonslocatedupstreamoftheclassicMBPexons.AlternativesplicingfromtheGolliandtheMBPtranscriptionstartsitesgivesriseto2setsofMBP-relatedtranscriptsandgeneproducts.TheGollimRNAscontain3exonsuniquetoGolli-MBP,splicedin-frameto1ormoreMBPexons.TheyencodehybridproteinsthathaveN-terminalGolliaasequencelinkedtoMBPaasequence.ThesecondfamilyoftranscriptscontainonlyMBPexonsandproducethewellcharacterizedmyelinbasicproteins.ThiscomplexgenestructureisconservedamongspeciessuggestingthattheMBPtranscriptionunitisanintegralpartoftheGollitranscriptionunitandthatthisarrangementisimportantforthefunctionand/orregulationofthesegenes.
      GeneSymbol
      • MBP
      • MGC99675
      • Golli-mbp
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P02686#TheclassicgroupofMBPisoforms(isoform4-isoform14)arewithPLPthemostabundantproteincomponentsofthemyelinmembraneintheCNS.Theyhavearoleinbothitsformationandstabilization.Thesmallerisoformsmighthaveanimportantroleinremyelinationofdenudedaxonsinmultiplesclerosis.Thenon-classicgroupofMBPisoforms(isoform1-isoform3/Golli-MBPs)maypreferentiallyhavearoleintheearlydevelopingbrainlongbeforemyelination,maybeascomponentsoftranscriptionalcomplexes,andmayalsobeinvolvedinsignalingpathwaysinT-cellsandneuralcells.Differentialsplicingeventscombinedtooptionalpost-translationalmodificationsgiveawidespectrumofisomers,eachofthemhavingmaybeaspecializedfunction.InducesT-cellproliferation.
      SIZE:304aminoacids;33117Da
      SUBUNIT:Homodimer;isoform3existsasahomodimer.
      SUBCELLULARLOCATION:Myelinmembrane;Peripheralmembraneprotein;Cytoplasmicside.Note=Cytoplasmicsideofmyelin.
      TISSUESPECIFICITY:MBPisoformsarefoundinboththecentralandtheperipheralnervoussystem,whereasGolli-MBPisoformsareexpressedinfetalthymus,spleenandspinalcord,aswellasincelllinesderivedfromtheimmunesystem.DEVELOPMENTALSTAGE:Expressionturnsonabruptlyinfetusof14to16weeks.Evensmallerisoformsseemtobeproducedduringembryogenesis,someofthesepersistingintheadult.ExpressionofisoformMBP2ismoreevidentat16weeksanditsrelativeproportiondeclinedthereafter.
      PTM:SeveralchargeisomersofMBP;C1(themostcationic,leastmodified,andmostabundantform),C2,C3,C4,C5,C6,C7,C8-AandC8-B(theleastcationicform);areproducedasaresultofoptionalPTM,suchasphosphorylation,deamidationofglutamineorasparagine,argininecitrullinationandmethylation.C8-AandC8-BcontaineachtwomassisoformstermedC8-A(H),C8-A(L),C8-B(H)andC8-B(L),(H)standingforhigherand(L)forlowermolecularweight.C3,C4andC5arephosphorylated.Theratioofmethylatedarginineresiduesdecreasesinaging,makingtheproteinmorecationic.&TheN-terminalalanineisacetylated(isoform3,isoform4,isoform5andisoform6).&Arg-241wasfoundtobe6%monomethylatedand60%symmetricallydimethylated.
      DISEASE:SwissProt:P02686#Thereductioninthesurfacechargeofcitrullinatedand/ormethylatedMBPcouldresultinaweakenedattachmenttothemyelinmembrane.Thismechanismcouldbeoperativeindemyelinatingdiseasessuchaschronicalmultiplesclerosis(MS),andfulminatingMS(Marburgdisease).
      SIMILARITY:SwissProt:P02686##Belongstothemyelinbasicproteinfamily.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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