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Millipore/AB9598 | Anti-Glial fibrillary acidic protein δ Antibody/AB9598/100 µL
  • Millipore/AB9598 | Anti-Glial fibrillary acidic protein δ Antibody/AB9598/100 µL

Millipore/AB9598 | Anti-Glial fibrillary acidic protein δ Antibody/AB9598/100 µL

價(jià)格: ￥4188.00 市場(chǎng)價(jià): 6980.00
貨號(hào): AB9598
品牌: Millipore
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    • Description
      CatalogueNumberAB9598
      Replaces04-1031;04-1062
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-GlialfibrillaryacidicproteinδAntibody
      AlternateNames
      • GFAPdelta
      BackgroundInformationHumanGlialFibrillaryAcidicProteindelta(GFAP-delta)isaGFAPproteinisoformthatisencodedbyanalternativesplicevariantoftheGFAP-gene.Asaresult,GFAP-deltaproteindiffersfromthepredominantspliceform,GFAP-alpha,byitsC-terminalproteinsequence.GFAP-deltaproteinisnotexpressedbyallGFAPexpressingastrocytesbutspecificallybyasubpopulationlocatedinthesubpialzoneofthecerebralcortex,thesubgranularzoneofthehippocampusand,mostintensely,byaribbonofastrocytesfollowingtheependymallayerofthecerebralventricles.Therefore,atleastinthesubventricularzone(SVZ),GFAP-deltaspecificallymarksthepopulationofastrocytesthatcontaintheneuralstemcellsintheadulthumanbrain.Interestingly,theSVZastrocytesactivelyspliceGFAP-deltatranscripts,incontrasttoastrocytesadjacenttothislayer.DatashowsthatGFAP-deltaprotein,unlikeGFAP-alpha,isnotupregulatedinastrogliosis.DataindicatesadifferentfunctionalroleforGFAP-deltainastrocytephysiology.TransfectionstudiesshowedthatGFAP-deltaproteinexpressionhasanegativeeffectonGFAPfilamentformation,andthereforecouldbeimportantformodulatingintermediatefilamentcytoskeletalproperties,possIBLyfacilitatingastrocytemotility.FurtherstudiesonGFAP-deltaandthecellsthatexpressitareimportantforgaininginsightsintoitsfunctionduringdifferentiation,migrationandduringhealthanddisease(Roelofs,RF,etal.,Glia(2005)52:289-300.).
      ProductInformation
      FormatSerum
      PresentationRabbitserum.Liquid.
      StorageandShippingInformation
      StorageConditionsMaintainat-20°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationAnti-GlialfibrillaryacidicproteinδAntibodyisanantibodyagainstGlialfibrillaryacidicproteinδforuseinWB,IH(P).
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      ApplicationNotesWesternblot:1:500withovernightincubation.Theantibodyrecognizesthe~60kDaGFAP-deltaprotein.

      Immunohistochemistry:1:500incubatedfor36-48hoursat2-8°Conparaffinembeddedtissuesections.Itissuggestedthatthetissuebetreatedwithmicrowaveantigenretrievalpriortostaining.

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidefromhumanGFAP-delta.
      HostRabbit
      SpecificityGlialFibrillaryAcidicProtein-delta(GFAP-delta).TheantibodydoesnotrecognizeGFAP-alphaprotein.
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteDoesNOTreactwithmouseorratGFAP-delta.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesoneofthemajorintermediatefilamentproteinsofmatureastrocytes.ItisusedasaMarkertodistinguishastrocytesfromotherglialcellsduringdevelopment.MutationsinthisgenecauseAlexanderdisease,araredisorderofastrocytesinthecentralnervoussystem.Anadditionaltranscriptvarianthasbeendescribed,butitsfulllengthsequencehasnotbeendetermined.
      GeneSymbol
      • GFAP
      • FLJ45472
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P14136#GFAP,aclass-IIIintermediatefilament,isacell-specificmarkerthat,duringthedevelopmentofthecentralnervoussystem,distinguishesastrocytesfromotherglialcells.
      SIZE:432aminoacids;49880Da
      SUBUNIT:Isoform3interactswithN-terminusofPSEN1.
      SUBCELLULARLOCATION:Cytoplasm.Note=Associatedwithintermediatefilaments.
      DISEASE:SwissProt:P14136#DefectsinGFAPareacauseofAlexanderdisease[MIM:203450].Alexanderdiseaseisararedisorderofthecentralnervoussystem.ItisaprogressiveleukoencephalopathywhosehallmarkisthewidespreadaccumulationofRosenthalfiberswhicharecytoplasmicinclusionsinastrocytes.Themostcommonformaffectsinfantsandyoungchildren,andischaracterizedbyprogressivefailureofcentralmyelination,usuallyleADIngtodeathusuallywithinthefirstdecade.InfantswithAlexanderdiseasedevelopaleukoencephalopathywithmacrocephaly,seizures,andpsychomotorretardation.Patientswithjuvenileoradultformstypicallyexperienceataxia,bulbarsignsandspasticity,andamoreslowlyprogressivecourse.
      SIMILARITY:SwissProt:P14136##Belongstotheintermediatefilamentfamily.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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