UniProtSummary | FUNCTION:SwissProt:Q9UIW2#CoreceptorforSEMA3A,SEMA3C,SEMA3FandSEMA6D.Necessaryforsignalingbyclass3semaphorinsandsubsequentremodelingoftheCytoskeleton.Playsaroleinaxonguidance,invasivegrowthandcellmigration.Class3semaphorinsbindtoacomplexcomposedofaneuropilinandaplexin.Theplexinmodulatestheaffinityofthecomplexforspecificsemaphorins,anditscytoplasmicdomainisrequiredfortheactivationofdown-streamsignalingeventsinthecytoplasm(Bysimilarity). SIZE:1896aminoacids;211087Da SUBUNIT:InteractsdirectlywithNRP1andNRP2.InteractswithFARP2,RND1andKDR/VEGFR2.BindingofSEMA3AleadstodissociationofFARP2(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein(Potential). TISSUESPECIFICITY:Detectedinfetalbrain,lung,liverandkidney. SIMILARITY:SwissProt:Q9UIW2##Belongstotheplexinfamily.&Contains4IPT/TIGdomains.&Contains1Semadomain. |