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Millipore/ABN37 | Anti-Homer1 Antibody/ABN37/100 µg
  • Millipore/ABN37 | Anti-Homer1 Antibody/ABN37/100 µg

Millipore/ABN37 | Anti-Homer1 Antibody/ABN37/100 µg

價格: ￥3948.00 市場價: 6580.00
貨號: ABN37
品牌: Millipore
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    • Description
      CatalogueNumberABN37
      DescriptionAnti-Homer1Antibody
      AlternateNames
      • Homerproteinhomolog1
      • Homer-1
      • Homer1
      BackgroundInformationHomerproteinhomolog1(UniProtQ86YM7;alsoknownasHomer-1,Homer1)isencodedbytheHOMER1(alsoknownasSYN47)gene(GeneID9456)inhuman.Homer-1,-2,and-3constituteafamilyofpostsynapticscaffoldproteinsthatplayacentralroleincalciumsignaling.HomermembersshareaconservedN-terminalEna/VASPhomology1(EVH1)domain(a.a.1-110ofHomer-1)thatmediatesignalingcomplexesassemblybyinteractingwithPPXXFRproline-richconsensussequencesfoundinvariousotherscaffoldingandsignaltransductionmolecules,includingmetabotropicglutamatereceptors(mGluRs)and1,4,5-trisphosphatereceptors(IP3Rs).InadditiontomediategroupImGluRssignalingviatheirEVH1domain,Homer-1splicedvariantsVesl-1L,1b,and1d,butnotVesl-1MorVesl-1S,alsocontainaC-terminalcoiled-coil(a.a.181-352)regionthatmediateself-multimerization.Homer-1variantsareassociatedwiththeetiologyofmanyneurologicaldiseases,suchaschronicpain,mentalretardationsyndromes,Alzheimer"sdisease(AD),Parkinson"sdisease(PD),schizophrenia,drug-inducedaddiction,andtraumaticbraininjury(TBI).Homer1b/c-knockdownisreportedtoprotectagainstchemicallyinducedseizureinmiceasaresultofpreventingmGluR5-mediatedmTORpathwayactivation.
      ProductInformation
      FormatAffinityPurified
      Control
      • Mousebraintissuelysate.
      PresentationPurifiedrabbitpolyclonalantibodyinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-Homer1,Cat.No.ABN37,isahighlyspecificrabbitpolyclonalantibodythattargetsHomerproteinhomolog1andhasbeentestedinImmunohistochemistryandWesternBlotting.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      ApplicationNotesImmunohsitochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedHomer1inhumanandmousecerebralcortextissuesections.

      ImmunohsitochemistryAnalysis:ArepresentativelotdetectedsignificantlyincreasedstratumrADIatumandstratumoriensHomer1immunoreactivityinfloatingbrainsectionsfrommicereceivedAP-12intraperitonealinjection(Jansone,B.,etal.(2015).PLoSOne.10(6):e0127686).
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtoaninternalsequencewithintheN-terminalhalfofhumanHomer1isoform1bandneartheC-terminusofisoform1h.
      ConcentrationPleaserefertolotspecificdatasheet.
      HostRabbit
      SpecificityThisrabbitpolyclonalantibodytargetsaninternalsequencewithintheN-terminalhalfofhumanHomer1isoform1bandmouseisoformVesl-1L.ImmunogensequenceappearsneartheC-terminusofhumanisoform1handmouseisoforms1b,1d,Vesl-1M,andVesl-1S,butabsentinhumanisoform1e.Highlyhomologoussequence(~83%)isalsofoundintheN-terminalhalfofratisoform1c(Vesl-1L)andneartheC-terminusofratisoforms1a(Vesl)and1b.
      SpeciesReactivity
      • Human
      • Mouse
      SpeciesReactivityNoteHuman,Mouse.PredictedtoreactwithHorseandMonkeybasedon100%sequencehomology.Broadspeciesreactivityexpectedbasedonhighsequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberofthehomerfamilyofdendriticproteins.Membersofthisfamilyregulategroup1metabotrophicglutamatereceptorfunction.
      GeneSymbol
      • HOMER1
      • SYN47
      PurificationMethodAffinitypurfied.
      UniProtNumber
      MolecularWeight~47kDaobserved.40.28/19.86kDa(humanisoform1b/1h),40.22/42.08/41.41/22.78/20.91kDa(mouseisoform1b/1d/Vesl-1L/Vesl-1M/Vesl-1S)calculated.Uncharacterizedbandsmaybeobservedinsomelysate(s).
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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