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Millipore/ABN55 | Anti-Netrin-1 Antibody/ABN55/100 µL
  • Millipore/ABN55 | Anti-Netrin-1 Antibody/ABN55/100 µL

Millipore/ABN55 | Anti-Netrin-1 Antibody/ABN55/100 µL

價格: ¥3816.00 市場價: 6360.00

貨號: ABN55
品牌: Millipore
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    • Description
      CatalogueNumberABN55
      DescriptionAnti-Netrin-1Antibody
      AlternateNames
      • netrin1,mouse,homologof
      • Netrin1
      • Ntn1
      BackgroundInformationNetrin-1isasecreted,bifunctionalligandbelongingtotheNetrinfamily;agroupofproteinsknowntoactasversatile,chemotropicaxonguidancecuesforCNScommissuralandperipheralmotoraxons.Netrin-1isnecessaryforspinalcordoligodendrocytedevelopment.TherearetworeceptorswithwhichNetrin-1isassociatedandthatwillcauseittobeeitherachemoattractantorachemorepellantforaxons.ReceptorDeletedinColorectalCancer(DCC)regulatestheattractionofaxonstoNetrin-1,andUNC5mediatesaxonrepulsionfromNetrin-1.StudieshaveshownNetrin-1tofunctionasasurvivalfactorthroughitsrelationshiptoitsreceptors,inhibitingtheonsetofapoptosis.Netrin-1hasalsobeenimplicatedincolorectaltumOrigenesisviaitsapoptoticregulatoryrole.ExpressionofNetrin-1hasbeendetectedinadultaxonsandoligodendrocytes,andisalsowidelyobservedindevelopingembryonicmesodermaltissuesandnervoussystem.
      ProductInformation
      FormatSerum
      Control
      • Mousebraintissuelysate
      PresentationRabbitpolyclonalserumcontaining0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationAnti-Netrin-1AntibodydetectslevelofNetrin-1&hasbeenpublished&validatedforuseinWB.
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenLinearpeptidecorrespondingtomouseNetrin-1.
      EpitopeUnknown
      HostRabbit
      IsotypeIgG
      SpeciesReactivity
      • Mouse
      • Rat
      SpeciesReactivityNoteDemonstratedtoreactwithmouseandrat.Otherhomologies:Human(94%sequencehomology).
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • NTN1
      • NTN1L
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:NetrinscontrolguidanceofCNScommissuralaxonsandperipheralmotoraxons.ItsassociationwitheitherDCCorsomeUNC5receptorswillleadtoaxonattractionorrepulsion,respectively.Italsoserveasasurvivalfactorviaitsassociationwithitsreceptorswhichpreventtheinitiationofapoptosis.Involvedincolorectaltumorigenesisbyregulatingapoptosis(Bysimilarity).

      SUBUNITSTRUCTURE:Bindstoitsreceptors;DCC,UNC5A,UNC5B,UNC5CandprobablyUNC5D(Bysimilarity).Bindstoitsreceptor;DSCAM.

      SUBCELLULARLOCATION:Secreted?extracellularspace?extracellularmatrix

      TISSUESPECIFICTY:Intheembryo,widelyexpressedinthedevelopingnervoussystemandinmesodermaltissues.

      SEQUENCESIMILARITIES:Contains3lamininEGF-likedomains.

      Contains1lamininN-terminaldomain.

      Contains1NTRdomain.
      MolecularWeight~68kDaobserved.CharacteristicproteolyticfragmentsofNetrin-1foundintheCNSrunatlowermolecularweights.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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