UniProtSummary | FUNCTION:NetrinscontrolguidanceofCNScommissuralaxonsandperipheralmotoraxons.ItsassociationwitheitherDCCorsomeUNC5receptorswillleadtoaxonattractionorrepulsion,respectively.Italsoserveasasurvivalfactorviaitsassociationwithitsreceptorswhichpreventtheinitiationofapoptosis.Involvedincolorectaltumorigenesisbyregulatingapoptosis(Bysimilarity).
SUBUNITSTRUCTURE:Bindstoitsreceptors;DCC,UNC5A,UNC5B,UNC5CandprobablyUNC5D(Bysimilarity).Bindstoitsreceptor;DSCAM.
SUBCELLULARLOCATION:Secreted?extracellularspace?extracellularmatrix
TISSUESPECIFICTY:Intheembryo,widelyexpressedinthedevelopingnervoussystemandinmesodermaltissues.
SEQUENCESIMILARITIES:Contains3lamininEGF-likedomains.
Contains1lamininN-terminaldomain.
Contains1NTRdomain. |