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Millipore/ABN78 | Anti-NeuN Antibody (rabbit)/ABN78/100 µg
  • Millipore/ABN78 | Anti-NeuN Antibody (rabbit)/ABN78/100 µg

Millipore/ABN78 | Anti-NeuN Antibody (rabbit)/ABN78/100 µg

價格: ￥4188.00 市場價: 6980.00
貨號: ABN78
品牌: Millipore
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    • Description
      CatalogueNumberABN78
      DescriptionAnti-NeuNAntibody(rabbit)
      AlternateNames
      • RNAbindingproteinfox-1homolog3
      • Fox-1homologC
      • Fox-3
      • Hexaribonucleotide-bindingprotein3
      • NeuN
      • Neuronalnuclei
      BackgroundInformationRNAbindingproteinfox-1homolog3(UniProtQ8BIF2;alsoknownasFox-1homologC,Fox-3,Hexaribonucleotide-bindingprotein3,NeuN,Neuronalnuclei)isencodedbytheRbfox3(alsoknownasD11Bwg0517e,Hrnbp3)gene(GeneID52897)inmurinespecies.TheRNA-bindingFox(Rbfox)familyofsplicingfactorsiscomprisedofthreemembers,Rbfox1(Fox-1orA2BP1),Rbfox2(Fox-2orRBM9),andRbfox3(Fox-3,HRNBP3orNeuN).Rbfoxproteinsregulatesplicingofmanyneuronaltranscripts(pre-mRNAs)bybindingthesequence(U)GCAUGinintronsflankingalternativeexons.A(U)GCAUGmotifthatliesdownstreamofthealternativeexongenerallypromotesRbfox-dependentexoninclusion,whereasanupstreammotifwillusuallyrepressexoninclusion.OriginallycharacterizedasaMarkerofpost-mitoticneuronsandnamedneuronalnuclei(NeuN),Rbfox3playsaroleinpromotingneuronaldifferentiationthroughalternativesplicingofNumbpre-mRNAduringbraindevelopment.Rbfox3-knockoutinmiceisreportedtoresultindefectivehippocampalgeneexpression,defectsinsynaptictransmissionandplasticityinthedentategyrus,aswellasincreasedseizuresusceptibilityanddecreasedanxiety-relatedbehaviors.Likewise,humanRBFOX3genemutationshavebeenlinkedtoneurodevelopmentaldelay,cognitiveimpairments,autisticfeatures,andepilepsy.
      ProductInformation
      FormatAffinityPurified
      Control
      • Mousebrainnuclearextract
      PresentationPurifiedrabbitpolyclonalantibodyinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-NeuN(rabbit)Antibody,Cat.No.ABN78,isahighlyspecificrabbitpolyclonalantibodythattargetsNeuNandhasbeentestedinImmunocytochemistry,Immunofluorescence,Immunohistochemistry,andWesternBlotting.
      KeyApplications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunofluorescence
      • WesternBlotting
      ApplicationNotesImmunocytochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedNeuNinculturedembryonicE18rathippocampusneurons.

      ImmunohistochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedNeuN-positiveneuronsinhuman(cerebellumandcerebralcortex)andmouse(hippocampus)braintissuesections.

      ImmunocytochemistryAnalysis:Arepresentativelotsimmunostained4%paraformaldehyde-fixedneuronsisolatedfromsnailbrain(Nikoli?,L.,etal.(2013).J.Exp.Biol.216(Pt18):3531-3541).

      ImmunofluorescenceAnalysis:RepresentativelotsdetectedNeuN-positiveneuronsinfrozenbrainsectionsfrom4%paraformaldehyde-perfusedmice(Cherry,J.D.,etal.(2015).J.Neuroinflammation.12:203;Huang,B.,etal.(2015).Neuron.85(6):1212-1226;Ataka,K.,etal.(2013).PLoSOne.8(11):e81744).

      ImmunofluorescenceAnalysis:ArepresentativelotsdetectedNeuN-positiveneuronsinformalin-fixedandparaffin-embeddedamyotrophiclateralsclerosis(ALS)humanbraintissuesections(Fratta,P.,etal.(2015).Neurobiol.Aging.36(1):546.e1-7).

      ImmunohistochemistryAnalysis:ArepresentativelotdetectedNeuN-positiveneuronsinratbraintissuesections(Mendon?a,M.C.,etal.(2013).Toxins.5(12):2572-2588).

      WesternBlottingAnalysis:RepresentativelotdetectedNeuNinmouseandratbraintissuelysates(Huang,B.,etal.(2015).Neuron.85(6):1212-1226;Mendon?a,M.C.,etal.(2013).Toxins.5(12):2572-2588).

      ThisrabbitpolyclonalantibodyisalsoavaiableasAlexaFluor?488(ABN78A4),biotin(ABN78B),andCy3(ABN78C3)conjugatesforimmunocytochemistry,immunofluorescence,immunohistochemistryapplications.
      BIOLOGicalInformation
      ImmunogenGST-taggedrecombinantmouseNeuNN-terrminalfragment.
      EpitopeN-terminus
      ConcentrationPleaserefertolotspecificdatasheet.
      HostRabbit
      SpecificityThisrabbitpolyclonalantibodytargetsNeuNN-terminalregionthatendsatthestartofRNArecognitionmotif(RRM).Targetregionispresentinallhuman,mouse,andratsplicedisoformsreportedbyUniProt(A6NFN3,Q8BIF2,D4A2H6,A0A0G2K2J4).
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Snail
      SpeciesReactivityNoteHuman,Mouse,Rat,Snail.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • Rbfox3
      • D11Bwg0517e
      • Hrnbp3
      PurificationMethodAffinityPurfied
      UniProtNumber
      MolecularWeight~48/42kDaobserved.33.87/35.12kDa(humanisoform1/2),40.61/39.05/35.64/34.07/35.63kDa(mouseisoform1/2/3/4/5),40.59kDa(rat;UniProtD4A2H6),34.05kDa(rat;UniProtA0A0G2K2J4)calculated.Uncharacterizedbandsmaybeobservedinsomelysate(s).
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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