Description: KP372-1directlyinhibitsthekinaseactivitiesofAkt,PDK1andFlt3(Fms-liketyrosinekinase3),whichareaberrantlyactivatedinacutemyelogenousleukemia(AML).Itisacellpermeantinhibitorthatdecreasesthecolony-formingABIlityofAMLcells(IC50< 200 nM) with minimal cytoxic effects on normal hematopoietic Progenitorcells.KP372-1hasalsobeenshowntosuppresscellproliferationandinduceapoptosisinthyroidcancercellsandgliobastoma.