Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3. This analog of PI(4,5)P2 is labeled with the red fluorophore Cyanine 5 (Cy5)
Categories | Lipids |
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Filter | Fluorescent, PI(4,5)P2 |
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Molecular Formula | C75H129N6O19P3 |
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Molecular Weight (g/mol) | 1511.80 |
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Excitation/Emission | 646/662 nm |
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Purity | 95% |
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Storage | -20 °C or below, protect from light |
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