Clone | APA5 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rat |
Specificity | SpecificallyrecognizesmouseCD140a,thealphachainofPDGFreceptor.Areceptortyrosinekinase,PDGFRaformsdimersonthesurfaceuponligandbindingandphosphorylatessubstrates.CD140aisexpressedbyembryonictissuesandmesenchymal-derivedcellsoftheadultmousetissues. |
Isotype | IgG2aκ |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesacellsurfacetyrosinekinasereceptorformembersoftheplatelet-derivedgrowthfactorfamily.Thesegrowthfactorsaremitogensforcellsofmesenchymalorigin.Theidentityofthegrowthfactorboundtoareceptormonomerdetermineswhetherthefunctionalreceptorisahomodimeroraheterodimer,composedofbothplatelet-derivedgrowthfactorreceptoralphaandbetapolypeptides.Studiesinknockoutmice,wherehomozygosityislethal,indicatethatthealphaformoftheplatelet-derivedgrowthfactorreceptorisparticularlyimportantforkidneydevelopmentsincemiceheterozygousforthereceptorexhibitdefectivekidneyphenotypes. |
GeneSymbol | - PDGFRA
- CD140a
- PDGFR2
- Rhe-PDGFRA
- PDGF-R-alpha
- CD140A
- MGC74795
- EC2.7.10.1
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P16234#ReceptorthatbindsbothPDGFAandPDGFBandhasatyrosine-proteinkinaseactivity. SIZE:1089aminoacids;122670Da SUBUNIT:Homodimer,andheterodimerwithPDGFRB.InteractswithSHB(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. DISEASE:SwissProt:P16234#AfusionofPDGFRAandFIP1L1(FIP1L1-PDGFRA),duetoaninterstitialchromosomaldeletion,isthecauseofsomecasesofhypereosinophilicsyndrome(HES)[MIM:607685].HESisararehematologicdisordercharacterizedbysustainedoverproductionofeosinophilsinthebonemarrow,eosinophilia,tissueinfiltrationandorgandamage. SIMILARITY:SwissProt:P16234##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.CSF-1/PDGFreceptorsubfamily.&Contains5Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain. |