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Abnova/MYC Split CISH Probe/1kit/CG0011
  • Abnova/MYC Split CISH Probe/1kit/CG0011

Abnova/MYC Split CISH Probe/1kit/CG0011

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貨號: CG0011
品牌: Abnova
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  • 詳情
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      • Specification
      • Gene Info
      • Pathway
      • Disease
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      • Specification
      • Product Description:
      • MYC Split CISH Probe is designed for the qualitative detection of human MYC gene at 8q24.21 in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
      • Recommend Usage:
      • The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18-25°C) and mix briefly before use.
      • Supplied Product:
      • Reagent Provided:1. Digoxigenin-labeled polynucleotides targeting sequences mapping in 8q24.21* (chr8:130,373,051-130,847,951) distal to the MYC breakpoint region2. Dinitrophenyl-labeled polynucleotides targeting sequences mapping in 8q24.21* (chr8:127,888,765-128,363,281) proximal to the MYC breakpoint region 3. Formamide based hybridization buffer*according to Human Genome Assembly GRCh37/hg19
      • Storage Instruction:
      • Store at 2-8°C in an upright position. Return to storage conditions immediately after use.
      • Note:
      • The probe is intended to be used in combination with the CISH Implementation Kit 2 (Catalog #: KA5366), which provides necessary reagents for specimen pretreatment and post-hybridization processing.Hybridization signals of digoxigenin-labeled polynucleotides appear dark green distinct dot-shaped (distal to the MYC breakpoint region), and dinitrophenyl-labeled polynucleotides appear bright red distinct dot-shaped (proximal to the MYC breakpoint region).Normal situation: In interphases of normal cells or cells without a translocation involving the MYC gene region, two red/green fusion signals appear.Aberrant situation: One MYC gene region affected by a translocation is indicated by one separate green signal and one separate red signal. Other signal distribution may be observed in some abnormal samples which might result in a different signal pattern than described above, indicating variant rearrangements. Unexpected signal patterns should be further investigated.
      • Probe Position:
      • Regulatory Status:
      • For research use only (RUO)
      • Interpretation of Result:
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Chromogenic In Situ Hybridization (FFPE Tissue)
      • Chromogenic <i>In Situ</i> Hybridization (FFPE Tissue)
      • Non-Hodgkin lymphoma tissue section with translocation affecting the 8q24.21 locus as indicated by one red/green fusion (non-rearranged) signal, one red signal, and one separate green signal.
      • Chromogenic In Situ Hybridization (Cells)
      • Chromogenic <i>In Situ</i> Hybridization (Cells)
      • Normal interphase cells as indicated by two red/green fusion signals per nucleus.
      • Application Image
      • Chromogenic In Situ Hybridization (FFPE Tissue)
      • Chromogenic <i>In Situ</i> Hybridization (FFPE Tissue)
      • enlarge
      • Chromogenic In Situ Hybridization (Cells)
      • Chromogenic <i>In Situ</i> Hybridization (Cells)
      • enlarge
      • Gene Information
      • Entrez GeneID:
      • 4609
      • Gene Name:
      • MYC
      • Gene Alias:
      • bHLHe39,c-Myc
      • Gene Description:
      • v-myc myelocytomatosis viral oncogene homolog (avian)
      • Omim ID:
      • 113970, 190080
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt"s lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
      • Other Designations:
      • avian myelocytomatosis viral oncogene homolog,myc proto-oncogene protein,v-myc avian myelocytomatosis viral oncogene homolog
      • Gene Pathway
      • Acute myeloid leukemia
      • Bladder cancer
      • Cell cycle
      • Chronic myeloid leukemia
      • Colorectal cancer
      • Endometrial cancer
      • ErbB signaling pathway
      • Jak-STAT signaling pathway
      • MAPK signaling pathway
      • Pathways in cancer
      • Small cell lung cancer
      • TGF-beta signaling pathway
      • Thyroid cancer
      • Wnt signaling pathway
      • Related Disease
      • Alzheimer Disease
      • Alzheimer disease
      • Breast cancer
      • Breast Neoplasms
      • Carcinoma, Non-Small-Cell Lung
      • Carcinoma, Squamous Cell
      • Cardiovascular Diseases
      • Chromosome Aberrations
      • Colorectal Neoplasms
      • Diabetes Complications
      • Disease Progression
      • Genetic Predisposition to Disease
      • Helicobacter Infections
      • Hematologic Diseases
      • Hodgkin Disease
      • Kidney Failure, Chronic
      • Lung Neoplasms
      • Lymphoma, B-Cell
      • Lymphoma, B-Cell, Marginal Zone
          • ... see more
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