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Abnova/MALT1 Split CISH Probe/1kit/CS0012
  • Abnova/MALT1 Split CISH Probe/1kit/CS0012

Abnova/MALT1 Split CISH Probe/1kit/CS0012

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貨號(hào): CS0012
品牌: Abnova
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  • 詳情
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      • Specification
      • Gene Info
      • Pathway
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • MALT1 Split CISH Probe is designed for the qualitative detection of human MALT1 gene at 18q21.32 in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
      • Recommend Usage:
      • The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18-25°C) and mix briefly before use.
      • Supplied Product:
      • Reagent Provided:1. Digoxigenin-labeled polynucleotides targeting sequences mapping in 18q21.31-q21.32* (chr18:56,021,766-56,202,885) proximal to the MALT1 breakpoint region2. Dinitrophenyl-labeled polynucleotides targeting sequences mapping in 18q21.32* (chr18:56,557,814-56,724,408) distal to the MALT1 breakpoint region 3. Formamide based hybridization buffer*according to Human Genome Assembly GRCh37/hg19
      • Storage Instruction:
      • Store at 2-8°C in an upright position. Return to storage conditions immediately after use.
      • Note:
      • The probe is intended to be used in combination with the CISH Implementation Kit 2 (Catalog #: KA5366), which provides necessary reagents for specimen pretreatment and post-hybridization processing.Hybridization signals of digoxigenin-labeled polynucleotides appear dark green distinct dot-shaped (proximal to the MALT1 breakpoint region), and dinitrophenyl-labeled polynucleotides appear bright red distinct dot-shaped (distal to the MALT1 breakpoint region).Normal situation: In interphases of normal cells or cells without a translocation involving the MALT1 gene region, two red/green fusion signals appear. Aberrant situation: One MALT1 gene region affected by a translocation is indicated by one separate green signal and one separate red signal. Other signal distribution may be observed in some abnormal samples which might result in a different signal pattern than described above, indicating variant rearrangements. Unexpected signal patterns should be further investigated.
      • Probe Position:
      • Regulatory Status:
      • For research use only (RUO)
      • Interpretation of Result:
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Chromogenic In Situ Hybridization (Cells)
      • Chromogenic <i>In Situ</i> Hybridization (Cells)
      • Normal interphase cells as indicated by two red/green fusion signals per nucleus.
      • Application Image
      • Chromogenic In Situ Hybridization (Cells)
      • Chromogenic <i>In Situ</i> Hybridization (Cells)
      • enlarge
      • Gene Information
      • Entrez GeneID:
      • 10892
      • Gene Name:
      • MALT1
      • Gene Alias:
      • DKFZp434L132,MLT,MLT1
      • Gene Description:
      • mucosa associated lymphoid tissue lymphoma translocation gene 1
      • Omim ID:
      • 604860
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
      • Other Designations:
      • MALT associated translocation,MALT-lymphoma associated translocation,caspase-like protein,mucosa associated lymphoid tissue lymphoma translocation protein 1,paracaspase
      • Gene Pathway
      • B cell receptor signaling pathway
      • T cell receptor signaling pathway
      • Related Disease
      • Gastritis
      • Genetic Predisposition to Disease
      • Helicobacter Infections
      • Lymphoma, B-Cell, Marginal Zone
      • Stomach Neoplasms
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