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Abnova/ACTN4/CEN19p FISH Probe (Orange/Green)/1kit/DF0002
  • Abnova/ACTN4/CEN19p FISH Probe (Orange/Green)/1kit/DF0002

Abnova/ACTN4/CEN19p FISH Probe (Orange/Green)/1kit/DF0002

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貨號(hào): DF0002
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  • 詳情
  • 使用說(shuō)明
  • 常見(jiàn)問(wèn)題
      • Specification
      • Gene Info
      • Interactome
      • Pathway
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique.
      • Storage Instruction:
      • Store at 2-8°C in the dark. Please aliquot before use.
      • Note:
      • Hybridization position of the probes on the chromosome.
      • Protocol:
      • PDF DownloadProtocol Download
      • Probe:Fluorophore:Location:
      • ACTN4/CEN19pTAMRA/FITC19q13/19p13.11
      • Origin:
      • Human
      • Source:
      • Genomic DNA
      • Regulation Status:
      • CE-IVDOther countries:For research use only (RUO)
      • Datasheet:
      • PDF DownloadDownload
      • Publication Reference
      • 1.
      • Prognostic impact of ACTN4 gene copy number alteration in hormone receptor-positive, HER2-negative, node-negative invasive breast carcinoma.Sugano T, Yoshida M, Masuda M, Ono M, Tamura K, Kinoshita T, Tsuda H, Honda K, Gemma A, Yamada T.Br J Cancer. 2020 Jun;122(12):1811-1817. doi: 10.1038/s41416-020-0821-y. Epub 2020 Apr 8.
      • 2.
      • Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer.Kakuya T, Mori T, Yoshimoto S, Watabe Y, Miura N, Shoji H, Onidani K, Shibahara T, Honda K.Int J Oral Maxillofac Surg. 2017 Apr 3. [Epub ahead of print]
      • 3.
      • Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4.Nami Miura, Masahiro Kamita, Takanori Kakuya, Yutaka Fujiwara, Koji Tsuta, Hideaki Shiraishi, Fumitaka Takeshita, Takahiro Ochiya, Hirokazu Shoji, Wilber Huang, Yuichiro Ohe, Tesshi Yamada, Kazufumi Honda.Oncotarget. 2016 April 21.
      • 4.
      • ACTN4 copy number increase as a predictive biomarker for chemoradiotherapy of locally advanced pancreatic cancer.Watanabe T, Ueno H, Watabe Y, Hiraoka N, Morizane C, Itami J, Okusaka T, Miura N, Kakizaki T, Kakuya T, Kamita M, Tsuchida A, Nagakawa Y, Wilber H, Yamada T, Honda KBr J Cancer. 2015 Feb 17;112(4):704-13. doi: 10.1038/bjc.2014.623. Epub 2015 Jan 20.
      • 5.
      • Copy number increase of ACTN4 is a prognostic indicator in salivary gland carcinoma.Watabe Y, Mori T, Yoshimoto S, Nomura T, Shibahara T, Yamada T, Honda KCancer Med. 2014 Feb 27. doi: 10.1002/cam4.214.
      • 6.
      • Distinct outcome of stage I lung adenocarcinoma with ACTN4 cell motility gene amplification.Noro R, Honda K, Tsuta K, Ishii G, Maeshima AM, Miura N, Furuta K, Shibata T, Tsuda H, Ochiai A, Sakuma T, Nishijima N, Gemma A, Asamura H, Nagai K, Yamada T.Ann Oncol. 2013 Jul 30.
      • Applications
      • DNA Hybridization
      • DNA Hybridizationenlargeenlarge this image
      • Human lung cancer (FFPE) stained with ACTN4/CEN19p FISH Probe (Orange/Green).
      • Application Image
      • DNA Hybridization
      • DNA Hybridization
      • enlarge
      • Gene Information
      • Entrez GeneID:
      • 81
      • Gene Name:
      • ACTN4
      • Gene Alias:
      • ACTININ-4,DKFZp686K23158,FSGS,FSGS1
      • Gene Description:
      • actinin, alpha 4
      • Omim ID:
      • 603278, 604638
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins.Alpha actinin is an actin-binding protein with multiple roles in different cell types.In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane.In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes.Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq
      • Other Designations:
      • actinin alpha4 isoform
      • Interactome
      • Interactome
      • Gene Pathway
      • Adherens junction
      • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
      • Focal adhesion
      • Leukocyte transendothelial migration
      • Regulation of actin cytoskeleton
      • Systemic lupus erythematosus
      • Tight junction
      • Related Disease
      • Alport syndrome
      • Cardiovascular Diseases
      • Diabetes Mellitus, Type 1
      • Diabetes Mellitus, Type 2
      • Diabetic Nephropathies
      • Edema
      • Genetic Predisposition to Disease
      • Glomerulosclerosis, Focal Segmental
      • Kidney Diseases
      • Proteinuria
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