Rabbit polyclonal antibody raised against ACTN4 protein.
Host:
Rabbit
Reactivity:
Human
Quality Control Testing:
Antibody reactive against recombinant protein.Western Blot detection against recombinant protein (58.41 KDa).Western Blot detection against recombinant protein (131.3 KDa).
Storage Buffer:
In 1x PBS, pH 7.4
Storage Instruction:
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Interspecies Antigen Sequence:
Mouse (98); Rat (98)
Datasheet:
Download
Applications
Western Blot
ELISA
Application Image
Western Blot
ELISA
Gene Information
Entrez GeneID:
81
GeneBank Accession#:
NM_004924.3
Protein Accession#:
NP_004915.2
Gene Name:
ACTN4
Gene Alias:
ACTININ-4,DKFZp686K23158,FSGS,FSGS1
Gene Description:
actinin, alpha 4
Omim ID:
603278, 604638
Gene Ontology:
Hyperlink
Gene Summary:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins.Alpha actinin is an actin-binding protein with multiple roles in different cell types.In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane.In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes.Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq
Other Designations:
actinin alpha4 isoform
Interactome
Gene Pathway
Adherens junction
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Focal adhesion
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Systemic lupus erythematosus
Tight junction
Related Disease
Alport syndrome
Cardiovascular Diseases
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Edema
Genetic Predisposition to Disease
Glomerulosclerosis, Focal Segmental
Kidney Diseases
Proteinuria
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ACTN4 & CTNNB1 Protein Protein Interaction Antibody Pair