The product is for research use only, not for use in diagnostic or therapeutic procedures
Product Name
Notch 1 (Cleaved-Val1754) Antibody
Synonyms
neurogenic locus notch 1; NOTC1; notch 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophila) (TAN1); Notch1; TAN1; translocation-associated notch protein TAN-1
Immunogen
The antiserum was produced against synthesized peptide derived from human Notch 1.
Immunogen Range
1735-1784
Clonality
Polyclonal
Application Dilutions
WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:5000
Specificity
Notch 1 (Cleaved-Val1754) Antibody detects endogenous levels of fragment of activated Notch 1 resulting from cleavage adjacent to Val1754.
Purification
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Physical Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/Stability
Stable at -20°C for at least 1 year.
NCBI Gene Symbol
NOTCH1
Database Links
Gene ID: 4851 Swiss-Prot #: P46531
OMIM #: 190198 Unigene #: Hs.495473
Target Modification
Cleaved
Modification Sites
H:V1754, M:V1744, R:V1744
Application Images
Image 1
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Notch 1 (Cleaved-Val1754) Antibody. The picture on the right is blocked with the synthesized peptide.
Image 2
Western blot analysis of lysates from NIH/3T3 cells, treated with Etoposide 25uM 60', using Notch 1 (Cleaved-Val1754) Antibody. The lane on the right is blocked with the synthesized peptide.