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Millipore/MAB1592 | Anti-Neurofilament H & M Antibody, phosphorylated, clone NP1/MAB1592/100 µL
  • Millipore/MAB1592 | Anti-Neurofilament H & M Antibody, phosphorylated, clone NP1/MAB1592/100 µL

Millipore/MAB1592 | Anti-Neurofilament H & M Antibody, phosphorylated, clone NP1/MAB1592/100 µL

價格: ￥4188.00 市場價: 6980.00
貨號: MAB1592
品牌: Millipore
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    • Description
      CatalogueNumberMAB1592
      Replaces04-1061
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-NeurofilamentH&MAntibody,phosphorylated,cloneNP1
      BackgroundInformationNeurofilamentsareatypeofintermediatefilamentthatserveasmajorelementsoftheCytoskeletonsupportingtheaxoncytoplasm.Theyarethemostabundantfibrillarcomponentsoftheaxon,beingonaverage3-10timesmorefrequentthanaxonalmicrotubules.Neurofilaments(10nmindia.)arebuiltfromthreeintertwinedprotofibrilswhicharethemselvescomposedoftwotetramericprotofilamentcomplexsofmonomericproteins.Theneurofilamenttripletproteins(68/70,160,and200kDa)occurinboththecentralandperipheralnervoussystemandareusuallyneuronspecific.The68/70kDaNF-Lproteincanself-assembleintoafilamentousstructure,howeverthe160kDaNF-Mand200kDaNF-Hproteinsrequirethepresenceofthe68/70kDaNF-Lproteintoco-assemble.Neuromas,ganglioneuromas,gangliogliomas,ganglioneuroblastomasandneuroblastomasstainpositivelyforneurofilaments.Althoughtypicallyrestrictedtoneurons,neurofilamentshavebeendetectedinparagangliomasandadrenalandextra-adrenalpheochromocytomas.Carcinoids,neuroendocrinecarcinomasoftheskin,andoatcellcarcinomasofthelungalsoexpressneurofilaments.FormoreneurofilamentinformationseeNervousSystemCellTypeSpecificMarkerchartonlineundertheCHEMICONTechnicalSupportsection.
      ProductInformation
      FormatAscites
      PresentationLiquid.Containsnopreservative.
      StorageandShippingInformation
      StorageConditionsMaintainat-20°Cinundilutedaliquotsforuptosixmonths.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationDetectNeurofilamentH&MusingthisAnti-NeurofilamentH&MAntibody,phosphorylated,cloneNP1validatedforuseinELISA,FC,RIA,WB,IC,IH(P).
      KeyApplications
      • ELISA
      • FlowCytometry
      • RADIoimmunoassay
      • WesternBlotting
      • Immunocytochemistry
      • Immunohistochemistry(Paraffin)
      ApplicationNotesWesternblot:recognizes,200kDa,and150kDaNF-HandNF-Mbandsprimarily.Stainingisremovedwithphosphatasetreatment.BecauseNF-Lalsocontainslysine-serinePO4sites,NP1maycrossreactwithNF-Laswell,butthishasnotbesubstantiatedintraditionalwesterns.

      Immunohistochemistry.Worksonparaffinembedded,formalinfixedandfrozenacteonefixedtissuesections.1:50-1:500forimmunofluorescence.

      ImmunocytochemistryonPC12,TERA-2andotherneuronallines.

      FACSELISA/RIA

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenBovineneurofilaments
      Epitopephosphorylated
      CloneNP1
      HostMouse
      SpecificityRecognizestheKSPrepeatsofthephosphorylatedformsofneurofilament-M(NF-M)andneurofilament-H(NF-H),becauseNF-LdoescontainafewoftheseLysine-serine-PO4-prolinerepeatssomecrossreactivitytoNF-Lmaybeseenatveryhighantibodyconcentrations.
      IsotypeIgG1
      SpeciesReactivity
      • Bovine
      • Chicken
      • Human
      • Rat
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • NEFH
      • NFH
      • NF-H
      • KIAA0845
      Modifications
      • Phosphorylation
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P12036#Neurofilamentsusuallycontainthreeintermediatefilamentproteins:L,M,andHwhichareinvolvedinthemaintenanceofneuronalcaliber.NF-HhasanimportantfunctioninmatureaxonsthatisnotsubservedbythetwosmallerNFproteins.
      SIZE:1026aminoacids;112480Da
      PTM:ThereareanumberofrepeatsofthetripeptideK-S-P,NFHisphosphorylatedonanumberoftheserinesinthismotif.ItisthoughtthatphosphorylationofNFHresultsintheformationofinterfilamentcrossbridgesthatareimportantinthemaintenanceofaxonalcaliber.&Phosphorylationseemstoplayamajorroleinthefunctioningofthelargerneurofilamentpolypeptides(NF-MandNF-H),thelevelsofphosphorylationbeingaltereddevelopmentallyandcoincidentwithachangeintheneurofilamentfunction.
      DISEASE:SwissProt:P12036#DefectsinNEFHareacauseofsusceptibilitytoamyotrophiclateralsclerosis(ALS)[MIM:105400].ALSisaneurodegenerativedisorderaffectingupperandlowermotorneurons,andresultinginfatalparalysis.Sensoryabnormalitiesareabsent.Deathusuallyoccurswithin2to5years.Theetiologyislikelytobemultifactorial,involvingbothgeneticandenvironmentalfactors.
      SIMILARITY:SwissProt:P12036##Belongstotheintermediatefilamentfamily.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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