Immunogen | Nucleifromadulthumanthymicbiopsyspecimens. |
Clone | LN-6 |
Host | Mouse |
Specificity | Reactswithhumanmesenchymalcellsandderivedsarcomas.Reactswithanepitopeofthecytoskeletalproteinvimentinbutunlikeothervimentinantibodies,doesnotreactwithhumanlymphoidcellsorderivedmalignancies.Reactivewithendothelium,muscle,fibroblasts,melanocytes,peripheralnerve,sertolicells,kidneymesangialcellsandtubules,osteoblastsandperiosteum,non-hematopoietictumorsofmesenchymalorigin(allsarcomas),meningiomasandmelanomas. |
Isotype | IgM |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | AlongwiththeMICROFILaments(actins)andmicrotubules(tubulins),theintermediatefilamentsrepresentathirdclassofwell-characterizedcytoskeletalelements.Thesubunitsdisplayatissue-specificpatternofexpression.Desmin(MIM125660)isthesubunitspecificformuscleandvimentinthesubunitspecificformesenchymaltissue.[suppliedbyOMIM] |
GeneSymbol | - VIM
- FLJ36605
- Vimentin.
- vimentin
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P08670#Vimentinsareclass-IIIintermediatefilamentsfoundinvariousnon-epithelialcells,especiallymesenchymalcells. SIZE:466aminoacids;53652Da SUBUNIT:Homopolymer.ComponentofacomplexcomposedatleastofACTB,AP2M1,AP2A1,AP2A2,MEGF10andVIM.InteractswithHCVcoreprotein. TISSUESPECIFICITY:Highlyexpressedinfibroblasts,someexpressioninT-andB-lymphocytes,andlittleornoexpressioninBurkitt"slymphomacelllines.Expressedinmanyhormone-independentmammarycarcinomacelllines. PTM:Oneofthemostprominentphosphoproteinsinvariouscellsofmesenchymalorigin.Phosphorylationisenhancedduringcelldivision,atwhichtimevimentinfilamentsaresignificantlyreorganized. SIMILARITY:SwissProt:P08670##Belongstotheintermediatefilamentfamily. |
MolecularWeight | 57-60kDa |