Specificity | ICAM-1belongstotheimmunoglobulinsuperfamily,C2subset.Itisatransmembranemoleculeof90kDwith7potentialN-glycosylationsites.Itisexpressedonrestingmonocytesandendothelialcellsandcanbeupregulatedonmanyothercells,e.g.withlymphokines,onBandTlymphocytes,thymocytes,dendriticcells,keratinocytes,chondrocytes,andepithelialcells.CD54mediatescelladhesionbindingtointegrinsCD11a/CD18(LFA-1)andtoCD11b/CD18(Mac-1).TheinteractionofCD54withLFA-1enhancesantigen-specificTcellactivation.CD54alsobindstoCD43andtoPlasmodiumfalciparum-infectederythrocytes. |