Mouse monoclonal antibody raised against 4-amino Biphenyl DNA.
Immunogen:
4-amino Biphenyl.
Host:
Mouse
Specificity:
This antibody is specific to 4-amino Biphenyl DNA.
Form:
Liquid
Recommend Usage:
Immunohistochemistry (1:50-1:100)Immunocytochemistry (1:50-1:100)The optimal working dilution should be determined by the end user.
Storage Buffer:
In buffer containing 0.09% sodium azide
Storage Instruction:
Store at 4°C for short term. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Publication Reference
1.
Evaluation of 4-aminobiphenyl-DNA adducts in human breast cancer: the influence of tobacco smoke.Faraglia B, Chen SY, Gammon MD, Zhang Y, Teitelbaum SL, Neugut AI, Ahsan H, Garbowski GC, Hibshoosh H, Lin D, Kadlubar FF, Santella RM.Carcinogenesis. 2003 Apr;24(4):719-25.
2.
Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity.McQueen CA, Chau B.Toxicol Sci. 2003 Jun;73(2):279-86. Epub 2003 Apr 15.
3.
Quantitative immunohistochemical analysis of 4-aminobiphenyl-DNA in cultured cells and mice: comparison to gas chromatography/mass spectroscopy analysis.al-Atrash J, Zhang YJ, Lin D, Kadlubar FF, Santella RM.Chem Res Toxicol. 1995 Jul-Aug;8(5):747-52.
Applications
Immunohistochemistry
Immunohistochemical analysis of 4-amino Biphenyl on human breast tumor tissue with high (A) and low (B) adduct levels using 4-amino Biphenyl monoclonal antibody, clone 4C11 (Cat # MAB2405). Images courtesy of Dr. Regina Santella.