Immunogen | Crudesynapticimmunoprecipitate(Human) |
Clone | SP15 |
Host | Mouse |
Specificity | Synaptophysin.ReactswithsynaptophysinexpressedinCHOcells. |
Isotype | IgM |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Synaptophysin(p38)isanintegralmembraneproteinofsmallsynapticvesiclesinbrainandendocrinecells.[suppliedbyOMIM] |
GeneSymbol | - SYP
- synaptophysin
- Synaptophysin
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P08247#PossIBLyinvolvedinstructuralfunctionsasorganizingothermembranecomponentsorintargetingthevesiclestotheplasmamembrane. SIZE:313aminoacids;33845Da SUBUNIT:Homohexamerorhomotetramer. SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Characteristicofatypeofsmall(30-80nm)neurosecretoryvesicles,includingpresynapticvesicles,butalsovesiclesofvariousneuroendocrinecellsofbothneuronalandepithelialphenotype. DOMAIN:SwissProt:P08247Thecalcium-bindingactivityisthoughttobelocalizedinthecytoplasmictailoftheprotein. PTM:Ubiquitinated;mediatedbySIAH1orSIAH2andleADIngtoitssubsequentproteasomaldegradation(Bysimilarity). SIMILARITY:Belongstothesynaptophysin/synaptobrevinfamily.&Contains1MARVELdomain. |