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Millipore/MAB3738 | Anti-PML Antibody, clone 36.1-104/MAB3738/100 µL
  • Millipore/MAB3738 | Anti-PML Antibody, clone 36.1-104/MAB3738/100 µL

Millipore/MAB3738 | Anti-PML Antibody, clone 36.1-104/MAB3738/100 µL

價格: ￥3816.00 市場價: 6360.00
貨號: MAB3738
品牌: Millipore
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    • Description
      CatalogueNumberMAB3738
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-PMLAntibody,clone36.1-104
      AlternateNames
      • PromyelocyticLeukemiaProtein
      • TripartiteMotifProtein19
      BackgroundInformationPMLproteinisatripartitemotif(TRIM)-containingnuclearproteinthatmayfunctionas,amongotherthings,atranscriptionfactor,acoactivatorofnuclearreceptors(Ruggerio,2000),aregulatorofapoptosis(Guo,2000),amediatorofinterferon-inducedantiviralresponse(RegandandChelbi-Aliz,2001),andasasuppressorofgrowthandoncogenictransformation(Mu,1997).PMLislocalizedtothenucleoplasmandindistinctsubnuclearstructuresreferredtoasPromyelocyticLeukemiaBodies(alsoknownasNuclearDomain10).LocalizationofPMLtoPromyelocyticLeukemiaBodiesrequiresmodificationofPMLproteinbytheSmallUbiquitinModifier(SUMO)andisrequiredforproperformationandintegrityofthesesubnuclearstructures.Atleast14splicevariantsofPMLranginginmolecularweightfrom48-97kDa(predicted)havebeendescribedintheliterature.Thefunctionalsignificanceofthevarioussplicevariantsisnotwellunderstood.InpatientswithAcutePromyelocyticLeukemia,thePMLgeneisinvolvedinatleasttwospecificchromosomaltranslocationsthatresultintheexpressionofchimericproteinswiththeRetinoicAcidReceptoralpha(RARalphaDNA-andHormone-bindingdomains;Pandolfi,2001).AllisoformsofPML,aswellasthePML-RARalphachimericproteinsexpressedinTypeAandTypeBAPLcontainanidenticalN-terminusbutvaryintheC-terminalportionoftheprotein(Jenson,2001).
      ProductInformation
      FormatAscites
      Control
      • POSITIVECONTROL:Mouseembryofibroblasts(MEF1cells).
      PresentationAscitesfluidcontainingnopreservatives.
      StorageandShippingInformation
      StorageConditionsMaintainfor1yearat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
      Applications
      ApplicationAnti-PMLAntibody,clone36.1-104isaMouseMonoclonalAntibodyfordetectionofPMLalsoknownasPromyelocyticLeukemiaProtein&hasbeenvalidatedinICC,IP&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesWesternblot(1:500)

      Immunoprecipitation

      Immunocytochemistry(1:100)

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenHis-taggedPMLfusionproteincorrespondingtoaminoacids1-581ofmousePML.
      Clone36.1-104
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityRecognizesmousePML(PromyelocyticLeukemiaprotein).Onwesternblotsofproteinextractsfrommouseembryofibroblast(MEF1cells),MAB3738recognizesabandmigratingatapproximately106kDacorrespondingtoPML.
      IsotypeIgG2b
      SpeciesReactivity
      • Mouse
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberofthetripartitemotif(TRIM)family.TheTRIMmotifincludesthreezinc-bindingdomains,aRING,aB-boxtype1andaB-boxtype2,andacoiled-coilregion.Thisphosphoproteinlocalizestonuclearbodieswhereitfunctionsasatranscriptionfactorandtumorsuppressor.Itsexpressioniscell-cyclerelatedanditregulatesthep53responsetooncogenicsignals.Thegeneisofteninvolvedinthetranslocationwiththeretinoicacidreceptoralphageneassociatedwithacutepromyelocyticleukemia(APL).Extensivealternativesplicingofthisgeneresultsinseveralvariationsoftheprotein"scentralandC-terminalregions;allvariantsencodethesameN-terminus.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified.
      GeneSymbol
      • PML
      • PP8675
      • RNF71
      • TRIM19
      • MYL
      Non-ReactiveSpecies
      • Human
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P29590#Probabletranscriptionfactor.MayplayanimportantroleinrecruitmentofELF4intoPMLnuclearbodies.
      SIZE:882aminoacids;97517Da
      SUBUNIT:InteractswithSIRT1,TOPBP1,TRIM27andTRIM69.InteractswiththeC-terminusofELF4.InteractswithLassavirusZproteinandrABIesvirusphosphoprotein(Bysimilarity).
      SUBCELLULARLOCATION:Nucleus.Note=LocalizedtoPMLnuclearbodies.
      PTM:Ubiquitinated;mediatedbySIAH1orSIAH2andleADIngtoitssubsequentproteasomaldegradation.
      DISEASE:SwissProt:P29590#AchromosomalaberrationinvolvingPMLmaybeacauseofacutepromyelocyticleukemia(APL).Translocationt(15;17)(q21;q21)withRARA.ThePMLbreakpoints(typeAandtypeB)lieoneithersideofanalternativelysplicedexon.
      SIMILARITY:SwissProt:P29590##Contains2Bbox-typezincfingers.&Contains1RING-typezincfinger.
      MolecularWeight106kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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