Mouse monoclonal antibody raised against native CD36.
Immunogen:
Native purified CD36 from human fetal red blood cells.
Host:
Mouse
Reactivity:
Human
Specificity:
The molecular weight of the recognized antigen is 90KDa. Recognizes the glycoprotein gp lllb corresponding to the thrombospondin receptor. This antibody agglutinates fetal but not adult erythrocytes. It does not react with lymphocytes and granulocytes. It reacts both with fetal and adult monocytes, megakaryocytes, platelets and reticulocytes. The thrombospondin receptor is a very early marker of erythroid differentiation.
Form:
Lyophilized
Isotype:
IgG1
Recommend Usage:
Immunofluorescence (2ug/5x105 cells)Flow Cytometry (2ug/5x105 cells)The optimal working dilution should be determined by the end user.
Storage Buffer:
Lyophilized from PBS (1mg/mL BSA)
Storage Instruction:
Store at 4°C on dry atmosphere.After reconstitution with deionized water, store at -20°C or lower.Aliquot to avoid repeated freezing and thawing.
Datasheet:
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Publication Reference
1.
Application of lyophilised human platelets for antibody detection in solid phase red cell adherence assay.Shengbao Duan, Mingyuan Wang, Shaohua Ding, Yezhou Chen, Shuangshi Wei, Wei Chen, Chun Zhang, Yong Li, Hongmei Wang.J Immunol Methods. 2020 Sep 15;112868. doi: 10.1016/j.jim.2020.112868. Online ahead of print.
2.
A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors.Edelman P, Vinci G, Villeval JL, Vainchenker W, Henri A, Miglierina R, Rouger P, Reviron J, Breton-Gorius J, Sureau C, et al..Blood. 1986 Jan;67(1):56-63.
Applications
Immunohistochemistry
Immunofluorescence
Flow Cytometry
Application Image
Immunohistochemistry
Immunofluorescence
Flow Cytometry
Gene Information
Entrez GeneID:
948
Gene Name:
CD36
Gene Alias:
CHDS7,FAT,GP3B,GP4,GPIV,PASIV,SCARB3
Gene Description:
CD36 molecule (thrombospondin receptor)
Omim ID:
173510, 248310, 608404, 610938, 611162
Gene Ontology:
Hyperlink
Gene Summary:
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations:
CD36 antigen,CD36 antigen (collagen type I receptor, thrombospondin receptor),PAS-4 protein,cluster determinant 36,fatty acid translocase,glycoprotein IIIb,leukocyte differentiation antigen CD36,platelet glycoprotein IV,scavenger receptor class B, member
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