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Millipore/MAB5284 | Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301/MAB5284/100 &mic
  • Millipore/MAB5284 | Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301/MAB5284/100 &mic

Millipore/MAB5284 | Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301/MAB5284/100 &mic

價(jià)格: ￥4188.00 市場(chǎng)價(jià): 6980.00
貨號(hào): MAB5284
品牌: Millipore
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    • Description
      CatalogueNumberMAB5284
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-ChondroitinSulfateProteoglycanAntibody,Brain(coreprotein),cloneCat-301
      AlternateNames
      • CSPG
      BackgroundInformationTheantigenrecognizedbythisclone,CAT-301isaproteoglycanthatisdevelopmentalyregulated,highmolecularchondroitinsulphateproteoglycanfoundontheextracellularsurfaceofmammalianneurons.ItisexpressedlateindevelopmentandalthoughnodefinitiverolehasbeenidentifiedforCAT-301,itisbelievedtohavearoleinthestABIlisationofsynapticstructure.

      Thenamederivesfromthenameofthemonoclonalantibodyoriginallyusedtoidentifiedbyitsexpression,whichwasdetectedimmunocytochemicaly



      DisruptionofthenormalpatternsofneuronalactivityduringthecriticalearlypostnatalperiodbyphysicalorbiochemicalmeansresultsinalargeandirreversIBLereductioninlevelsofCAT-301.Similarinterventioninmatureanimalshasnoeffect



      CAT-301isrelatedtoaggrecanfromarticularcartilage.TheCAT-301antibodyimmunoreactswithaggrecan,andthechondroitinasetreatedaggrecanandCAT-301bothhaveapparentsizesof550kDa.HoweverCAT-301isnotglycosylatedbykeratansulphate,asaggrecanis.
      ProductInformation
      FormatPurified
      PresentationPurifiedimmunoglobulin.Liquid.Buffer=0.02MPhosphatebuffer,0.25MNaCl,pH7.6with0.1%sodiumazide.
      StorageandShippingInformation
      StorageConditionsMaintainat2-8°Cinundilutedaliquotsforupto6months.
      Applications
      ApplicationAnti-ChondroitinSulfateProteoglycanAntibody,Brain(coreprotein),cloneCat-301detectslevelofChondroitinSulfateProteoglycan&hasbeenpublished&validatedforuseinIP,WB,IC,IH.
      KeyApplications
      • Immunoprecipitation
      • WesternBlotting
      • Immunocytochemistry
      • Immunohistochemistry
      ApplicationNotesImmunohistochemistry:1:500-1:2,000on4%paraformaldehydefixedfrozentissue.

      Immunocytochemistry

      Immunoblot

      Immunoprecipitation

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenFelinespinalcordfixedgraymatter.
      EpitopeBrain(coreprotein)
      CloneCat-301
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityChondroitinsulfateproteoglycan(CSPG),braincoreprotein.
      IsotypeIgG1
      SpeciesReactivity
      • GuineaPig
      • Human
      • Hamster
      • Rat
      • Feline
      • Gerbil
      • Primate
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneisamemberoftheaggrecan/versicanproteoglycanfamily.Theencodedproteinisanintegralpartoftheextracellularmatrixincartilagenoustissueanditwithstandscompressionincartilage.Mutationsinthisgenemaybeinvolvedinskeletaldysplasiaandspinaldegeneration.Multiplealternativelysplicedtranscriptvariantsthatencodedifferentproteinisoformshavebeenobservedinthisgene.
      GeneSymbol
      • ACAN
      • MSK16
      • SEDK
      • CSPCP
      • AGCAN
      • AGC1
      • CSPG1
      • CSPGCP
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P16112#Thisproteoglycanisamajorcomponentofextracellularmatrixofcartilagenoustissues.Amajorfunctionofthisproteinistoresistcompressionincartilage.ItbindsavidlytohyaluronicacidviaanN-terminalglobularregion.
      SIZE:2415aminoacids;250193Da
      SUBUNIT:InteractswithFBLN1(Bysimilarity).
      SUBCELLULARLOCATION:Secreted,extracellularspace,extracellularmatrix(Bysimilarity).
      TISSUESPECIFICITY:Restrictedtocartilages.
      DEVELOPMENTALSTAGE:Expressionwasdetectedinchondrocytesthroughoutthedevelopingskeleton.
      DOMAIN:SwissProt:P16112Twoglobulardomains,G1andG2,comprisetheN-terminusoftheproteoglycan,whileanotherglobularregion,G3,makesuptheC-terminus.G1containsLinkdomainsandthusconsistsofthreedisulfide-bondedloopstructuresdesignatedastheA,B,B"motifs.G2issimilartoG1.Thekeratansulfate(KS)andthechondroitinsulfate(CS)attachmentdomainsliebetweenG2andG3.
      PTM:Containsmostlychondroitinsulfate,butalsokeratansulfatechains,N-linkedandO-linkedoligosaccharides.Thereleaseofaggrecanfragmentsfromarticularcartilageintothesynovialfluidatallstagesofhumanosteoarthritisistheresultofcleavagebyaggrecanase.
      DISEASE:SwissProt:P16112#DefectsinAGC1arethecauseofspondyloepiphysealdysplasiatypeKimberley(SEDK)[MIM:608361].Spondyloepiphysealdysplasiasareaheterogeneousgroupofcongenitalchondrodysplasiasthatspecificallyaffectepiphysesandvertebrae.TheautosomaldominantSEDKisassociatedwithprematuredegenerativearthropathy.
      SIMILARITY:Belongstotheaggrecan/versicanproteoglycanfamily.&Contains1C-typelectindomain.&Contains1EGF-likedomain.&Contains1Ig-likeV-type(immunoglobulin-like)domain.&Contains4Linkdomains.&Contains1Sushi(CCP/SCR)domain.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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